Skip to main content

P79 - AsthmaVent – effect of mechanical ventilation on asthmacontrol in house dust mite allergic children with asthma

Background

House dust mite allergy is a frequent cause of asthma in children. Children with house dust mite allergy and asthma are especially sensitive to physical and chemical agents in the indoor air and as children spend a lot of time indoors, it seems reasonable to believe that improving the indoor environment will lead to an improvement in asthma disease. At present, there is no clear consensus on the effect of ventilation on asthmatic children with house dust mite allergy. Earlier studies have been criticized for being small, poorly carried out and inconclusive. Thus there is a need for a powerful and methodologically rigorous study to provide significant evidence as a basis for the future treatment of children with house dust mite allergy and asthma.

Objective

This study started in the fall 2012 and aims at investigating whether mechanical ventilation is able to improve asthma symptoms during the winter season for children with house dust mite allergy and asthma.

Materials and methods

The study is a randomized double-blind placebo-controlled intervention study, with 9 months of intervention and follow-up. 80 children are included from 3 Danish hospitals and are randomized into two groups. The intervention is mechanical ventilation in the child’s bedroom. We monitor indoor air quality and health outcomes every three months. Primary outcomes are minimal effective dose of inhalation steroids and reduction in levels of particulate matter and house dust mite allergen.

Perspectives

Asthma patients and their families rely on good evidence-based advice on behavior and design of housing, so that the specific and non-specific factors in the indoor environment that trigger the disease are controlled as well as possible. The results of this project will be a significant contribution to the recommendations that can be given in relation to the effect of ventilation on indoor air quality in the asthma control of house dust mite allergic children.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Nina Viskum Hogaard.

Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.

The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Viskum Hogaard, N. P79 - AsthmaVent – effect of mechanical ventilation on asthmacontrol in house dust mite allergic children with asthma. Clin Transl Allergy 4, P134 (2014). https://doi.org/10.1186/2045-7022-4-S1-P134

Download citation

Keywords

  • Asthma
  • Mechanical Ventilation
  • Indoor Environment
  • Asthma Control
  • House Dust