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P45 - Early exclusive breastfeeding protects from preschool wheeze


Thus far, exhaustive research has been conducted on a potential link of breastfeeding (BF) to wheezing illnesses. Nevertheless, conflicting evidence often emerges with several investigators reporting BF to protect from asthma, whereas others fail to show such a link; reports of an asthma-favoring role of BF can also be found. We therefore opted to explore the relation of different infantile feeding patterns with wheeze/asthma prevalence, in a cross-sectional, population-based study in preschool children.


Wheeze ever, doctor-diagnosed asthma and perinatal data were reported via questionnaire by parents of 1871 children aged 1-5. Information on feeding practices (exclusive breastfeeding vs mixed vs formula) and their duration (two vs four vs six months) was collected. Anthropometric measurements were conducted. Logistic regression models were build in the Statistical Package for Social Sciences (SPSS version 20.0), with the wheeze/asthma variables as main outcomes. A two-tailed p value less that 0.05, was considered statistically significant.


Using the 6 months of exclusive BF as reference and following adjustment for several confounding factors (maternal prenatal smoking, maternal age at birth, gestational age, birth weight, gender, parity, passive smoking at home, parental educational level, current BMI/waist circumference and history of atopic dermatitis), we find that all regimes that did not include at least 2 months of exclusive BF were positively associated with ever wheeze (OR 1.36-2.17. 95%CI=1-3.55 p=0.001-0.044). Conversely, regimes including early exclusive BF of as low as 2 and 4 months did not positively correlate to ever wheeze (OR 0.92-1.45. 95%CI=0.53-2.88 p=0.08-0.77); Diverse BF regimes were not differentially associated with reports of doctor-diagnosed asthma (p>0.05).


Early exclusive BF is associated with reduced prevalence of ever wheeze in preschoolers.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Guibas, G.V., Xepapadaki, P., Moschonis, G. et al. P45 - Early exclusive breastfeeding protects from preschool wheeze. Clin Transl Allergy 4 (Suppl 1), P100 (2014).

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