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O15 - Component resolved diagnosis: performance of specific IgE to alternaria compared to Alt a 1


As the panel of molecules available for component resolved diagnosis is being expanded our objective was to compare the performance of specific IgE to Alt a 1 and to Alternaria.

Material and methods

Specific IgE (ImmunoCAP®, Thermo Fisher Scientific) to Alternaria (cost ≈ 8 -9 €) and to Alt a 1 (cost ≈ 11-12 €) were measured simultaneously in children with symptoms of asthma and/or rhinoconjunctivitis who had positive skin tests to Alternaria. Values <0.35 kUA/L were considered negative.


We studied 143 children (92 M/51 F) aged 2.4 - 15.6 years. Negative results were found in 20 (14%) with Alternaria, 24 (16.8%) with Alt 1, and 19 with both (13.3%). There was a good correlation between the two determinations (r = 0.935, p <0.001). Overall the levels were higher for Alt a 1 (18.9 ± 24.4) than for Alternaria (15.4 ± 20.1). There were 97 cases (68%) with levels of Alt a 1 > Alternaria, 42 (29%) with Alt a 1 < Alternaria, and four with the same values. There was a single patient with positive Alt a 1 (0.39) and negative Alternaria (0.3), and five patients with negative Alt a 1 and positive Alternaria, with values of 0.43, 0.56, 2.3 , 7.4 and 11.3, two of which are not considered very meaningful.


The performance of specific IgE against Alternaria and Alt a 1 in detection of positive cases is similar. Only 2% of the cases appear to be sensitized to other molecules different from Alt a 1, and could go unnoticed if only the latter determination is requested. On the other hand, current vaccines standardized in biological units are based on whole Alternaria, and those in weight/volume are based on Alt a 1.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Lafuente, I., Pina, R., Uixera, S. et al. O15 - Component resolved diagnosis: performance of specific IgE to alternaria compared to Alt a 1. Clin Transl Allergy 4 (Suppl 1), O15 (2014).

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