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O14 - Der p 10 as a minor allergen in children sensitised to house dust mites


To assess the proportion of children with specific IgE to Der p 10 in children with sensitization to house dust mites (HDM).

Material and methods

We determined specific IgE (ImmunoCAP®, Thermo Fisher Scientific) to Der p 1, Der p 2 and Der p 10 simultaneously in children with symptoms of asthma and/or rhinoconjunctivitis who had positive skin tests to HDM. Values <0.35 kUA/L were considered negative.


We studied 232 children (147 M/85 F) aged 1.25 - 16.7 years. Negative results were found in 50 (21.6%) with Der p 1, 53 (22.8%) with Der p 2, 208 (89.7%) with Der p 10, and 29 with all three (12.5%). There were 24 patients with positive IgE to Der p 10: three of these had IgE values of 6.1 to 11 kUA/L to Der p 10 and negative results to Der p 1 and 2 (0.1 to 0.18), three had much higher IgE to Der p 10 (79.9 to >100) than to Der p 1 or 2 (0,58 to 24.2), and one slightly higher IgE to Der p 10 (2.8) than to Der p 1 or 2 (0.8 and 1.19). The rest of the patients had clearly lower IgE to Der p 10.


About 10% of patients sensitized to HDM had specific IgE to Der p 10. Sensitization to Der p 10 without sensitization to major allergens Der p 1 and Der p 2 appeared in 1.3% of patients, and serologically more relevant sensitization to Der p 10 in an additional 1.3% of patients. This should be considered when prescribing immunotherapy, as Der p 10 is not standardized in current vaccines.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Lafuente, I., Pina, R., Uixera, S. et al. O14 - Der p 10 as a minor allergen in children sensitised to house dust mites. Clin Transl Allergy 4 (Suppl 1), O14 (2014).

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