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  • Open Access

O11 - Cor a 14: the missing link in the molecular diagnosis of hazelnut allergy?

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Clinical and Translational Allergy20144 (Suppl 1) :O11

https://doi.org/10.1186/2045-7022-4-S1-O11

  • Published:

Keywords

  • Dermatitis
  • Systemic Reaction
  • Atopic Dermatitis
  • Early Onset
  • Control Individual

Background

Hazelnut (Corylus avellana) allergy shows age and geographic related sensitization profiles that have not been fully resolved.

Objectives

To study sensitization to hazelnut components in different age groups of hazelnut allergic patients and infants with atopic dermatitis (AD) sensitized to hazelnut in a birch-endemic region.

Methods

Seventy-five hazelnut allergic patients, 14 infants below 1 year of age with AD sensitized to hazelnut and 15 age related healthy control individuals were tested for IgE reactivity to rCor a 1.04, rCor a 8, rCor a 9, nCor a 11, rCor a 14 by ImmunoCAP and rBet v 1 by ISAC 103 microarray.

Results

Thirty-seven patients suffered from a systemic reaction and 38 patients reported an oral allergy syndrome (OAS) after eating hazelnut. In the population with systemic reactions, sensitization to Cor a 14 was seen in 19/20 preschoolchildren (median age (range) 2.6 years (1.0 – 5.4)), 8/10 schoolchildren (10.2 years (8.0 – 13.8 )) and 2/7 adults (28 years (18 – 33)) whereas sensitization to Cor a 9 was observed in 16/20 preschoolchildren, 7/10 schoolchildren and 3/7 adults. A minority of 13/37 and 5/37 was sensitized to Cor a 11 and Cor a 8. Combining of Cor a 14 and Cor a 9 enables us to correctly diagnose respectively 100 %, 80 % and 43 % of systemic reactions in preschool-, schoolchildren and adults. In contrast sensitization to Cor a 1.04 was generally associated with OAS, IgE reactivity to Cor a 1.04 was observed in respectively 6/7, 8/9 and 22/22 of preschool- , schoolchildren and adults. Sensitization to Cor a 14 was seen in two patients with OAS, although these sIgE levels to Cor a 14 were significantly lower. Twenty-one percent of the infants with AD showed Cor a 14 sensitization, whereas 4/14 and 1/14 showed IgE reactivity to Cor a 9 and Cor a 11.

Conclusion

Quantification of Cor a 14 can be of great value in hazelnut allergy diagnosis. Sensitization to Cor a 14 predominantly occurs in pre- and schoolchildren with severe hazelnut allergy and can have early onset (< 1 year of age).

Authors’ Affiliations

(1)
Department of Immunology-Allergology-Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerpen, Belgium
(2)
Department of Immunology-Allergology-Rheumatology, Antwerp University Hospital, Antwerpen, Belgium
(3)
Department of Pediatrics, Antwerp University Hospital, Antwerpen, Belgium

Copyright

© Faber et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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