Table 1 Challenge data and patients characteristics
Group 1 | Oral wheat allergy | ||||||
|---|---|---|---|---|---|---|---|
Patient no. | Age (y) | Sex | Atopic diseases | Symptoms at challenge | Other food allergies | Threshold (g) | Outgrown |
1 | 0.7 | M | AD, AB | U, E | Rye | 0.75 | Ch + An |
2 | 0.7 | M | AD, AB | U, D, V | 20.0 | An | |
3 | 0.7 | M | AD | U | Egg, Milk, Rye | 8.84 | Ch + An |
4 | 0.8 | M | AD, AB | U, A, C, E, P | Cashew, Egg, Pistacio | 15.75 | An |
5 | 0.8 | F | AD, AR, AB | U, V | Egg | 7.75 | Ch + An |
6 | 0.9 | M | AD, AB | U | Egg | 25.0 | Ch + An |
7 | 0.9 | M | AD, AR | U, R, C, V | Egg, Milk, Rye | 7.75 | Ch + An |
8 | 1.4 | M | AD | U | Egg | 25.0 | Ch + An |
9 | 1.5 | M | AD | U, AB, V | Rye | 4.0 | No |
10 | 2.1 | M | AD, AR, AB | U, C, D, E, R | Egg, Milk | 15.75 | Ch + An |
11 | 2.5 | F | AD | U, E, OAS | Egg, Milk, Poppy seeds | 0.25 | Ch + An |
12 | 2.7 | M | AD, AB | U | Egg, Hazelnut, Peanut | 25.0 | An |
13 | 3.0 | M | AD, AR, AB | U | Egg | 7.75 | No |
14 | 3.6 | M | AD, AR, AB | U, P | Melon, Milk, Rye | 8.0 | Ch + An |
15 | 5.6 | M | AD | U | 25.0 | Ch + An | |
Negative 16-48 | Age 0–6, F = 7, M = 26 | AD = 27, AR = 5, AB = 5 | Egg = 15, Milk =6, Peanut = 6, Hazelnut =3 Soya = 1, Lamb =1, Shrimp = 1, None = 1 | ||||
Negative 49-59 | Age 7–18, F = 5, M = 6 | AD = 6, AR = 7, AB = 7 | Egg = 3, Milk = 2, Peanut = 1, None = 8 | ||||
60 | 33.5 | F | U, C, R | 36.0 | No | ||
61 | 37.6 | F | AR | U, E | 3.91 | No | |
62 | 38.5 | M | U, OAS, P | Rye | 50.0 | No | |
63 | 41.7 | F | AR | U, OAS, P | 50.0 | No | |
64 | 52.2 | F | AR | OAS, P | 50.0 | No | |
65 | 73.4 | F | AR | U, AB, C, R | 6.0 | No | |
Negative 66-95 | Age 19–67.4, F = 23, M = 7 | AD = 4, AR = 11, AB = 7 | Egg = 1, Plaice = 1, Sesame = 1, None = 27 | ||||
Group 2 | Inhalation wheat allergy | ||||||
Patient no. | Age (y) | Sex | Atopic diseases | Symptoms at challenge | Other inhalant allergies | Occupation | Outgrown |
96 | 23.0 | F | R, AB | Baker | No | ||
97 | 25.4 | F | R, C | Durum, Rye | Baker | No | |
98 | 29.5 | F | R | Chef | No | ||
99 | 29.9 | M | R, C | Baker | No | ||
100 | 24.0 | M | AR | R, C | Rye | Baker | No |
101 | 25.7 | F | AD, AR | R, AB | Baker | No | |
102^ | 37.3 | F | AR | R | Grahpic designer | No | |
103^ | 40.2 | M | R | Rye | Pizza baker | - | |
104 | 41.1 | F | R, C | Chef | - | ||
105 | 41.6 | M | R, C | Pizza baker | No | ||
106 | 43.5 | F | AR | R, C | Baker | No | |
107* | 17.6 | F | Spelt | Student | No | ||
108* | 33.8 | M | Durum, Rye | Baker | No | ||
Group 3 | Wheat dependent exercise induced anaphylaxis | ||||||
Patient no. | Age (y) | Sex | Atopic diseases | Symptoms at challenge | sIgE to ω-5 gliadin (kUI/l) | Challenge dose (g) | Serum lactate (mM) |
109 | 23.0 | M | U | 14.9 | 44.0 | 11.6 | |
110 | 27.1 | F | AD | U | 11.5 | 44.0 | 2.3 |
111 | 27.4 | F | AB | U | < 0.35 | 44.0 | 5.9 |
112 | 29.7 | F | U, A | < 0.35 | 44.0 | 2.3 | |
113 | 32.4 | F | U | < 0.35 | 44.0 | 12.6 | |
114 | 38.1 | F | U | 29.4 | 14.7 | 3.4 | |
115 | 41.7 | M | U | 36.6 | 44.0 | 3.1 | |
116 | 42.2 | M | U | 11.0 | 44.0 | - | |
117 | 51.2 | M | U | 22.7 | 44.0 | 4.8 | |
118 | 67.2 | M | U | 8.2 | 29.3 | - | |
Negative 119-123 | Age 7–18.9, F = 2, M = 3 | AD = 1, AR = 0, AB = 1 | n = 0/5 (0%) | mean 49.8 [44.0-73.0] | mean 10.0 [7.1-12.9] | ||
Negative 124-156 | Age 19–63.0, F = 14, M = 19 | AD = 2, AR = 9, AB = 1 | n = 20/33 (61%) mean 6.7 [0–46.7] | mean 45.4 [14.3-58.7] | mean 11.5 [4.0-18.7] | ||