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Figure 1 | Clinical and Translational Allergy

Figure 1

From: Allergic sensitization: screening methods

Figure 1

Overlap of the X-ray crystal structures of natural Der p 1 in complex with an Fab of the mAb 4C1 (cyan) with the X-ray crystal structure of Der f 1 in complex with the same antibody fragment (violet). The structures show the molecular basis of cross-reactivity between both dust mite allergens: the Fab recognizes the same area in Der p 1 and Der f 1, which is a conformational epitope overlapping with an IgE antibody binding site[24].

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