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Component resolved diagnosis in relation to severity of hazelnut allergy across Europe


Hazelnut is one of the most common food allergies across Europe although sensitization profiles to specific hazelnut allergens differ between countries. We aim explore geographical differences across Europe regarding molecular sensitization profiles and asses possible associations with severity of hazelnut allergy.


This study was part of EuroPrevall, a multi-center European study on food allergies. A cohort of 2272 subjects from 12 European countries with reported allergy to at least one of 24 common foods was tested by ImmunoCAP (CAP) and skin prick test (SPT) to a panel of 24 foods, 12 inhalant allergens and latex. Subjects with a convincing history of hazelnut allergy (n=739) were included in this study. Component-resolved diagnosis (CRD) was performed on 426/739 with well-characterized purified recombinant (r) Cor a 1 (Bet v 1-homologue), rCor a 2 (profilin), rCor a 8 (LTP), rCor a 9 (legumin), rCor a 11 (vicilin), nCor a 12 (oleosin), rCor a 14 (2S albumin) and MUXF (CCD). Double-blind placebo-controlled (DBPCFC) food challenges were performed with 128 subjects.


Hazelnut ranked 1st across Europe in an outpatient clinic population, with 739subjects (32.5 %) reporting a convincing clinical history, ranging from 26.4% to 68.6% in Czech Republic, Poland, the Netherlands, France, United Kingdom, Italy, Switzerland and Lithuania and 4.9-12.0% in Spain, Bulgaria, Iceland and Greece. Sensitization to Cor a 1 was most prevalent in countries with a high percentage of birch pollen allergy. Cor a 8 sensitization was mostly seen in Greek patients (83%) and to a lesser extent in Spain (36.6%). Sensitization other allergens was in general much lower although present in subgroups of the population; Cor a 9 sensitization was observed more often in younger patients and Cor a 8, Cor a 9, Cor a 11, Cor a 12 and Cor a 14 were more prevalent in atopic dermatitis patients. Studies into putative associations between hazelnut allergens and symptom severity are still ongoing and will also be stratified on geographical area.


The outcome of this study so far confirms the results from previous studies. This standardized multinational study provides a unique set of data regarding hazelnut allergy and sensitization profiles.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Datema, M., Zuidmeer, L., Garino, C. et al. Component resolved diagnosis in relation to severity of hazelnut allergy across Europe. Clin Transl Allergy 3 (Suppl 3), P39 (2013).

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