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Non-IgE-mediated food allergy: a tolerance induction protocol


Cow’s milk proteins allergy (CMPA) is the most common food allergy in childhood, affecting up to 2.5% of infants. The immune mechanisms underlying non-IgE-mediated clinical presentations, which mostly affect the gastrointestinal system and are sometimes very severe, are not fully understood. Currently, specific oral tolerance induction (SOTI) is available as a specific treatment for CMPA, but most studies of this approach have focused on IgE-mediated forms of this food allergy.


Children, with non-IgE-mediated CMPA, underwent SOTI using a protocol consisting of oral ingestion of increasing doses of cow’s milk, always in Hospital settings, until reaching a 200 mL dose per day, before introduction of an unrestricted diet.


Five children aged from 19 months to 4 years (3 males, 2 females) with a history of CMPA, since the first year of life and predominantly manifested by gastrointestinal symptoms, were included. All patients have completed the protocol and remain on an unrestricted diet. During SOTI three children had mild to moderate reactions, mainly abdominal pain and with spontaneous resolution, but sometimes justifying protocol adjustment.


Despite clinical and immunological differences between IgE and non IgE CMPA, this protocol appears also to be a safe and effective alternative in the management of non-IgE-mediated CMPA, reducing the risk of accidental reactions and improving quality of life of chidren and their families. Nevertheless further studies are needed to validate this procedure.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Arêde, C., Cabral, A., Piedade, S. et al. Non-IgE-mediated food allergy: a tolerance induction protocol. Clin Transl Allergy 3 (Suppl 3), P19 (2013).

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