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Succesful oral desensitization in a teenage boy with severe cow’s milk allergy
Clinical and Translational Allergy volume 3, Article number: P122 (2013)
Severe cow’s milk allergy can cause life-threatening reactions. Specific oral desensitization (SOD) can be effective and improve quality of life of the children and their families.
A fourteen-year old boy was referred to our clinic for follow-up with the diagnosis of cow’s milk allergy. At 3 months of age, he had immediate rash around his mouth and vomiting when he was first introduced with infant formula. Since then, he was on a milk restriction diet. He had three anaphylactic reactions needing emergency visit, and epinephrine injections. His last anaphylactic reaction was 2 months before the referral. His serum specific IgE was 49.8 kU/L.
Specific oral desensitization (SOD) was performed according to protocol developed by Longo et al. The protocol consisted of 2 phases; the first phase was applied at hospital and the second phase was continued at home. The first phase was completed when 20 ml pure cow’s milk was achieved. The second phase was applied at home by the parents with gradual increase in milk dose.
During hospital admission he had two mild reactios needing antihistamines and nebulised adrenaline. He is still at the second phase of the protocol now. He can tolerate 200 ml of cow’s milk now; he can eat yoghurt instead of milk (half of daily amount of milk).
SOD can be effective and life-saving treatment especially for children with severe cow’s milk allergy to overcome life-threatening episodes of accidental ingestions.
Disclosure of interest
Barbi e, Longo G, Berti I, Matarazzo L, Rubert L, Saccari A, Lenisa I, Ronfani L, Radillo O, Ventura A: Adverse effects during specific oral tolerance induction: in home phase. Allergol Immunopathol (Madr). 2012, 40 (1): 41-50. 10.1016/j.aller.2011.05.004.
Barbi E, Longo G, Berti I, Neri E, Saccari A, Rubert L, Matarazzo L, Montico M, Ventura A: Adverse effects during specific oral tolerance induction: in-hospital "rush" phase. Eur Ann Allergy Clin Immunol. 2012, 44 (1): 18-25.
Longo G, Barbi E, Berti I, Meneghetti R, Ronfani L, Pittalis A, Ventura A: Specificoral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol. 2008, 121 (2): 343-7. 10.1016/j.jaci.2007.10.029.
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Tamay, Z., Aliyev, B., Dilek, F. et al. Succesful oral desensitization in a teenage boy with severe cow’s milk allergy. Clin Transl Allergy 3, P122 (2013). https://doi.org/10.1186/2045-7022-3-S3-P122
- Restriction Diet
- Infant Formula
- Anaphylactic Reaction
- Daily Amount