Volume 3 Supplement 2

9th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2013): Abstracts

Open Access

Smoking and non-allergic sinonasal disease

  • Vibeke Backer1,
  • Christian von Buchwald2,
  • Kåre Håkansson3,
  • Simon Francis Thomsen1 and
  • Allan Linneberg4
Clinical and Translational Allergy20133(Suppl 2):O11

https://doi.org/10.1186/2045-7022-3-S2-O11

Published: 16 July 2013

Background

The association between smoking and lower airway inflammation and disease is well documented; however, it is not established whether smoking also induces disease of the upper airways. In a previous study, we found non-allergic rhinitis (NAR) to be associated with smoking in a dose-dependent manner; in addition, asthma and chronic bronchitis were linked with NAR. In the present study, we re-test the hypothesis that smoking can cause non-allergic sinonasal disease.

Method

A cross-sectional study of a random population sample (n=3762; age, 18--69 years) was conducted in Copenhagen, Denmark. Study subjects were invited to a general health examination that included questions about airway diseases, a skin prick test (SPT) to common aeroallergens, and measurement of pulmonary function; 1522 (40.5%) persons accepted. For further analysis, we divided the population into the following groups: (I) negative SPT and persistent symptoms of sinonasal disease lasting more than four weeks (non-allergic chronic rhinosinusitis); (II) positive SPT and rhinitis (allergic rhinitis); (III) no rhinitis with or without positive SPT (background).

Results

We found that non-allergic chronic rhinosinusitis in comparison with the background group was associated with ever smoking (odds ratio [OR] = 1.60 [1.00--2.55]), asthma (OR = 2.52 [1.35--4.90]) and chronic bronchitis (OR = 2.26 [1.26--4.04]). Mean spirometric values were not significantly decreased in any group. The association with chronic bronchitis was stronger in non-allergic chronic rhinosinusitis than in allergic rhinitis, whereas the opposite was observed for asthma.

Conclusion

This study confirms that both smoking and chronic bronchitis are associated with non-allergic sinonasal disease. We conclude that smoking, at least in some cases, can be a triggering factor for the development of non-allergic sinonasal disease.

Authors’ Affiliations

(1)
Dept of Respiratory Medicine L, Bispebjerg Hospital
(2)
Dept of Head and Neck Surgery, Copenhagen University Hospital
(3)
Copenhagen University Hospital
(4)
Glostrup Hospital, Centre for Prevention and Health

Copyright

© Backer et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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