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  • Open Access

On-line Italian register for severe/non-controlled asthma

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Clinical and Translational Allergy20133 (Suppl 1) :P16

  • Published:


  • Asthma
  • National Health Service
  • Severe Asthma
  • Community Respiratory
  • Uncontrolled Asthma


Severe/Non-controlled asthma (SNCA) is a crucial challenge for physicians and a socio-economic burden for National Health Services (NHS). In Italy more than 50% of costs for asthma (1-2% of total NHS expenditure) are due to SNCA and moreover, within the European Community Respiratory Health Survey, Italy was the country with the lowest % of ICS daily use (29%) and with the highest % of subjects with uncontrolled asthma despite treatment (67% vs an overall European mean of 47%). Despite few data from very selected centers, in our country a precise estimate of the epidemiological figures and the disease related costs for SNCA is not available. Thus, we aimed at instituting of an on-line Italian register for SNCA (Registro Italiano Asma Grave e Non Controllata) published on the website of the Italian Health Agency (Istituto Superiore di Sanità -ISS) and financed by the Italian Drug Agency (Agenzia Italiana per il Farmaco AIFA). Objectives To assess in general population and in clinical settings the effectiveness of therapeutic strategies for SNCA, defined in accordance with GINA guidelines. Secondary objectives are: obtain clinical indicators of diagnostic and therapeutic appropriateness for SNCA, evaluate direct and indirect costs of this disease, obtain continuous monitoring of SNCA patients, some epidemiological figures and finally disseminate the use of the register among Italian clinical centers.


The register is composed of 9 different sections and a follow-up section accessible, at present, only to the 8 centers participating in the AGAVE (severe asthma: epidemiological and clinical cohorts follow up; therapeutic appropriateness and outcome assessment) project, financed by AIFA. These centers will use the register to enter clinical data from their SNCA patients. All patients with a diagnosis of severe asthma since at least one year and all uncontrolled asthma despite regular treatment according to GINA step 3 or 4 are eligible. Patients will be selected from prospective and retrospective longitudinal studies of pre-existing cohorts of different age groups and different geographical areas. Follow-up will be performed every 6 months for 24 months. The estimated number of recruited patients from the clinical setting is 375, while 500 patients are expected from the epidemiological setting.


Our goal is to collect more data on SNCA patients and disseminate the on-line register for use by National Health Service physicians.

Authors’ Affiliations

Consiglio Nazionale delle Ricerche, Istituto di Fisiologia Clinica, Italy
Università degli Studi di Palermo, Malattie dell’Apparato Respiratorio, Italy
Azienda Ospedaliera Universitaria Ospedali Riuniti di Ancona, Dipart Malattie Respiratorie e Immunoallergiche, Italy
Unità di Epidemiologica e Statistica Medica, Università di Verona, Italy
Dipartimento di Epidemiologia, Regione Lazio, Italy
Dipartimento Cardio Toracico e Vascolare, Università di Pisa, Italy
Dip Medicina, Malattie Allergiche e Respiratorie, Università di Genova, Italy
Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Italy


© Bresciani et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.