Skip to main content

Table 2 Summary of ROC analysis for three-gene-mean

From: A qPCR-based metric of Th2 airway inflammation in asthma

  Primary cohort Secondary cohort
  4 weeks 8 weeks 4 weeks 8 weeks
AUC 0.94 0.87 0.77 0.91
Sensitivity (%) three-gene-mean threshold*     
0.1 100 100 100 100
0.5 100 100 100 100
0.57 100 100 75 100
Specificity (%) three-gene-mean threshold*     
0.1 56 50 33 27
0.5 69 63 42 36
0.57 81 75 42 45
  1. * For the baseline three-gene-mean thresholds, the cutoff of 0.5 is suggested by the two peaks in Figure 1, the cutoff of 0.1 is derived from the mean + 2SD of the healthy distribution, and the cutoff of 0.57 maximizes the sum of sensitivity and specificity of the three-gene-mean in the primary cohort at 8 weeks.