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Table 3 Specific serum immunoglobulins before and after treatment and the post/pre ratios for the different regimens

From: Open-label parallel dose tolerability study of three subcutaneous immunotherapy regimens in house dust mite allergic patients

 

Regimen

Immunoglobulin

Visit

Slow

Interme-diate

Fast

Overall

IgE Der p (kUA/l)

Pre-T

13.0 ± 17.6

16.8 ± 18.5

36.0 ± 62.9

23.4±41.1

Post-T

46.3 ± 77.5

34.4 ± 44.6

53.2 ± 72.2

43.0±59.8

Ratio

3.6

2.0

1.5

1.8

IgE Der f (kUA/l)

Pre-T

15.3 ± 20.9

19.0 ± 21.8

38.1 ± 79.4

25.5 ± 50.9

Post-T

61.3 ± 108.5

36.5 ± 49.3

56.7 ± 101.2

47.5 ± 79.3

Ratio

4.0

1.9

1.5

1.9

IgE nDer p 1 (kUA/l)

Pre-T

6.0 ± 6.6

7.4 ± 6.4

9.9 ± 10.2

8.1 ± 8.0

Post-T

21.3 ± 30.1

19.8 ± 17.1

26.2 ± 22.1

22.4 ± 20.6

Ratio

3.8

2.7

2.6

2.8

IgE rDer p2 (kUA/l)

Pre-T

12.1 ± 19.8

14.9 ± 22.3

35.8 ± 72.3

22.2 ± 47.2

Post-T

28.9 ± 52.8

24.0 ± 33.0

59.1 ± 103.1

38.1 ± 70.8

Ratio

2.4

1.6

1.7

1.7

IgG 4 Der p (μg/l)

Pre-T

62.1 ± 54.2

128.2 ± 92.5

142.4 ± 176.6

125.6 ± 126.4

Post-T

1923.0 ± 2656.3

2993.3 ± 3577.2

3961.0 ± 4862.4

3228.3 ± 3997.3

Ratio

27.8

23.3

27.8

25.7

IgG 4 Der f (μg/l)

Pre-T

67.1 ± 52.2

151.8 ± 161.2

152.1 ± 216.7

140.7 ± 174.0

Post-T

2445.8 ± 3552.9

2597.3 ±3340.4

3546.2 ± 4954.4

2942.8 ± 3986.7

Ratio

36.4

17.1

23.3

20.9

IgG 4 nDer p1 (μg/l)

Pre-T

17.3 ± 9.1

51.3 ± 75.1

36.0 ± 25.7

41.2 ± 55.9

Post-T

739.8 ± 732.3

2128.7 ± 3087.8

1470.9 ± 1406.2

1697.6 ± 2352.7

Ratio

42.8

41.5

40.9

41.2

IgG 4 rDer p2 (μg/l)

Pre-T

9.2 ± 12.1

45.2 ± 49.8

79.5 ± 139.0

53.1 ± 92.5

Post-T

1531.0 ± 2126.3

2039.8 ± 2165.6

3295.4 ± 4468.6

2457.5 ± 3245.3

Ratio

166.4

45.1

41.5

46.3

IgG nDer p1 (μg/l)

Pre-T

620.0 ± 389.4

767.4 ±729.4

675.7 ± 384.6

714.2 ± 574.8

Post-T

2132 ± 1045.7

2835.3 ± 2095.1

2490.0 ± 1048.8

2612.3 ± 1631.2

Ratio

3.4

3.7

3.7

3.7

IgG rDer p2 (μg/l)

Pre-T

674.0 ± 343.1

740.0 ± 529.4

715.7 ± 454.9

722.4 ± 471.4

 

Post-T

1986.0 ± 978.3

3241.1 ± 2155.4

4405.3 ± 2699.8

3527.9 ± 2375.9

 

Ratio

2.9

4.4

6.2

4.9

  1. nDer = native Dermatophagoides pteronyssinus; rDer = recombinant Dermatophagoides pteronyssinus.
  2. Pre-T = pre-treatment; Post-T = post-treatment; Ratio = Post/Pre-treatment ratio.