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Table 3 Specific serum immunoglobulins before and after treatment and the post/pre ratios for the different regimens

From: Open-label parallel dose tolerability study of three subcutaneous immunotherapy regimens in house dust mite allergic patients

  Regimen
Immunoglobulin Visit Slow Interme-diate Fast Overall
IgE Der p (kUA/l) Pre-T 13.0 ± 17.6 16.8 ± 18.5 36.0 ± 62.9 23.4±41.1
Post-T 46.3 ± 77.5 34.4 ± 44.6 53.2 ± 72.2 43.0±59.8
Ratio 3.6 2.0 1.5 1.8
IgE Der f (kUA/l) Pre-T 15.3 ± 20.9 19.0 ± 21.8 38.1 ± 79.4 25.5 ± 50.9
Post-T 61.3 ± 108.5 36.5 ± 49.3 56.7 ± 101.2 47.5 ± 79.3
Ratio 4.0 1.9 1.5 1.9
IgE nDer p 1 (kUA/l) Pre-T 6.0 ± 6.6 7.4 ± 6.4 9.9 ± 10.2 8.1 ± 8.0
Post-T 21.3 ± 30.1 19.8 ± 17.1 26.2 ± 22.1 22.4 ± 20.6
Ratio 3.8 2.7 2.6 2.8
IgE rDer p2 (kUA/l) Pre-T 12.1 ± 19.8 14.9 ± 22.3 35.8 ± 72.3 22.2 ± 47.2
Post-T 28.9 ± 52.8 24.0 ± 33.0 59.1 ± 103.1 38.1 ± 70.8
Ratio 2.4 1.6 1.7 1.7
IgG 4 Der p (μg/l) Pre-T 62.1 ± 54.2 128.2 ± 92.5 142.4 ± 176.6 125.6 ± 126.4
Post-T 1923.0 ± 2656.3 2993.3 ± 3577.2 3961.0 ± 4862.4 3228.3 ± 3997.3
Ratio 27.8 23.3 27.8 25.7
IgG 4 Der f (μg/l) Pre-T 67.1 ± 52.2 151.8 ± 161.2 152.1 ± 216.7 140.7 ± 174.0
Post-T 2445.8 ± 3552.9 2597.3 ±3340.4 3546.2 ± 4954.4 2942.8 ± 3986.7
Ratio 36.4 17.1 23.3 20.9
IgG 4 nDer p1 (μg/l) Pre-T 17.3 ± 9.1 51.3 ± 75.1 36.0 ± 25.7 41.2 ± 55.9
Post-T 739.8 ± 732.3 2128.7 ± 3087.8 1470.9 ± 1406.2 1697.6 ± 2352.7
Ratio 42.8 41.5 40.9 41.2
IgG 4 rDer p2 (μg/l) Pre-T 9.2 ± 12.1 45.2 ± 49.8 79.5 ± 139.0 53.1 ± 92.5
Post-T 1531.0 ± 2126.3 2039.8 ± 2165.6 3295.4 ± 4468.6 2457.5 ± 3245.3
Ratio 166.4 45.1 41.5 46.3
IgG nDer p1 (μg/l) Pre-T 620.0 ± 389.4 767.4 ±729.4 675.7 ± 384.6 714.2 ± 574.8
Post-T 2132 ± 1045.7 2835.3 ± 2095.1 2490.0 ± 1048.8 2612.3 ± 1631.2
Ratio 3.4 3.7 3.7 3.7
IgG rDer p2 (μg/l) Pre-T 674.0 ± 343.1 740.0 ± 529.4 715.7 ± 454.9 722.4 ± 471.4
  Post-T 1986.0 ± 978.3 3241.1 ± 2155.4 4405.3 ± 2699.8 3527.9 ± 2375.9
  Ratio 2.9 4.4 6.2 4.9
  1. nDer = native Dermatophagoides pteronyssinus; rDer = recombinant Dermatophagoides pteronyssinus.
  2. Pre-T = pre-treatment; Post-T = post-treatment; Ratio = Post/Pre-treatment ratio.