Figure 4

Time course (A) and area under the curve (AUC) (B) of the lung resistance and Evans blue dye (EBD) levels in airway tissue (C) induced by intratracheal instillation of OVA in double sensitized (OVA and TMA) guinea pigs. The immediate airway response and EBD exudation to OVA challenge was inhibited by either repeated exposure to 0.03% OVA or 0.03% TMA-GPSA on five consecutive days. PIA: proximal intrapulmonary airways, DIA: distal intrapulmonary. Data are expressed as mean ± SEM, Mann-Whitney U test, *p < 0.05, n = 7 in each group.