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Table 5 Comparison of different techniques

From: Diagnostic tools in Rhinology EAACI position paper

Method Advantage Disadvantage
Nasal blown secretions - easy to perform - subject must be able to blow nose
- no information about mucosa
Nasal lavage - easy to perform
- luminal proteins, cells, mediators and cytokines
- reliability depends ability of subject to close nasopharynx
- dilution of mediators and cytokines
- variable recovery of fluid
- no information about mucosa
Sinus packs or filter paper - no/limited dilution of mediators - may irritate the nose
- cannot collect cells
- no information about mucosa
- more difficult than lavage
Microsuction technique - no dilution of mediators - representative sample?
- technically difficult
- cannot collect cells
- no information about mucosa
Nasal brush - sample of epithelium - no sample of deeper layers
- no information about nasal lumen
- technically more difficult
Nasal scraping - sample of epithelium - no sample of deeper layers
- no information about nasal lumen
- technically more difficult
Nasal NO - non-invasive - measure of inflammation and blockage
Nasal biopsy - sample of total nasal mucosa - no information about nasal lumen
- technically difficult