Eczema phenotypes and risk of allergic and respiratory conditions in school age children

Table 2 Associations of eczema phenotypes with lung function and current asthma in children at age 10 years

	FVC Z-score (95% CI)	FEV₁ Z-score (95% CI)	FEV₁/FVC Z-score (95% CI)	FEF₇₅ Z-score (95% CI)	Current asthma at 10 years odds ratio (95% CI)
Never eczema	Reference	Reference	Reference	Reference	Reference
Ever eczema	0.08 (0.01, 0.16)	0.08 (0.00, 0.16)	0.00 (− 0.07, 0.08)	0.02 (− 0.05, 0.09)	6.38 (4.61, 8.83)
Never	Reference	Reference	Reference	Reference	Reference
Early transient	0.04 (− 0.07, 0.14)	0.00 (− 0.10, 0.11)	− 0.02 (− 0.23, 0.19)	− 0.05 (− 0.15, 0.05)	4.82 (3.29, 7.08)
Mid-transient	− 0.07 (− 0.20, 0.05)	− 0.08 (− 0.21, 0.05)	− 0.04 (− 0.15, 0.07)	− 0.03 (− 0.15, 0.09)	2.68 (1.58, 4.57)
Late transient	0.11 (0.00, 0.21)	0.05 (− 0.06, 0.16)	− 0.11 (− 0.22, 0.00)	− 0.03 (− 0.13, 0.08)	3.07 (1.94, 4.87)
Persistent	0.04 (− 0.16, 0.24)	0.00 (− 0.21, 0.21)	− 0.02 (− 0.23, 0.19)	− 0.00 (− 0.20, 0.19)	11.53 (6.65, 20.01)

Values are Z-score mean differences for lung function measurements and odds ratios (95% confidence intervals) for current asthma from linear and logistic regression models for never/ever eczema. Values are average Z-score mean differences for lung function measurements and average odds ratios (95% confidence intervals) for current asthma from linear and logistic regression models, respectively, after multiple sampling based on 150 imputed datasets for eczema phenotypes. Lung function outcomes are force expiratory volume in 1 second (FEV₁), forced vital capacity (FVC), force expiratory flow at 75% of the exhaled FVC (FEF₇₅). Full models were adjusted for parental history of allergy, asthma or eczema, maternal education, parity, child’s sex, ethnicity and breastfeeding. Italic values indicate statistical significance at the α = 0.05 level

ISSN: 2045-7022