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  1. Letter to the Editor

    Food allergy in a child with de novo KAT6A mutation

    Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is...

    Varpu Elenius, Tuire Lähdesmäki, Marja Hietala and Tuomas Jartti

    Clinical and Translational Allergy 2017 7:19

    Published on: 22 June 2017

  2. Research

    The impact of penicillin allergy labels on antibiotic and health care use in primary care: a retrospective cohort study

    Suspected penicillin allergy (Pen-A) is often not verified by diagnostic testing. In third line penicillin allergy labels were associated with prescription of broad spectrum antibiotics, hospital stay duration...

    Tanly Su, Berna D. L. Broekhuizen, Theo J. M. Verheij and Heike Rockmann

    Clinical and Translational Allergy 2017 7:18

    Published on: 7 June 2017

  3. Review

    Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report

    This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is t...

    C. Cingi, P. Gevaert, R. Mösges, C. Rondon, V. Hox, M. Rudenko, N. B. Muluk, G. Scadding, F. Manole, C. Hupin, W. J. Fokkens, C. Akdis, C. Bachert, P. Demoly, J. Mullol, A. Muraro…

    Clinical and Translational Allergy 2017 7:17

    Published on: 1 June 2017

  4. Review

    Quality indicators for the acute and long-term management of anaphylaxis: a systematic review

    The quality of acute and long-term anaphylaxis management is variable and this contributes to the poor outcomes experienced by many patients. Clinical practice guidelines have the potential to improve outcomes...

    Sangeeta Dhami, Aadam Sheikh, Antonella Muraro, Graham Roberts, Susanne Halken, Monserat Fernandez Rivas, Margitta Worm and Aziz Sheikh

    Clinical and Translational Allergy 2017 7:15

    Published on: 24 May 2017

  5. Meeting abstracts

    Abstracts from the 3rd International Severe Asthma Forum (ISAF)

    M. E. Ketelaar, K. Van De Kant, F. N. Dijk, E. M. M. Klaassen, N. Grotenboer, M. C. Nawijn, E. Dompeling, G. H. Koppelman, Clare Murray, Philip Foden, Lesley Lowe, Hannah Durrington, Adnan Custovic, Angela Simpson, Andrew J. Simpson, Dominick E. Shaw…

    Clinical and Translational Allergy 2017 7(Suppl 2):14

    Published on: 24 May 2017

    This article is part of a Supplement: Volume 7 Supplement 2

  6. Review

    Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

    The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing...

    Jolanda H. M. van Bilsen, Edyta Sienkiewicz-Szłapka, Daniel Lozano-Ojalvo, Linette E. M. Willemsen, Celia M. Antunes, Elena Molina, Joost J. Smit, Barbara Wróblewska, Harry J. Wichers, Edward F. Knol, Gregory S. Ladics, Raymond H. H. Pieters, Sandra Denery-Papini, Yvonne M. Vissers, Simona L. Bavaro, Colette Larré…

    Clinical and Translational Allergy 2017 7:13

    Published on: 12 May 2017

  7. Research

    Early childhood risk factors for rhinoconjunctivitis in adolescence: a prospective birth cohort study

    Rhinoconjunctivitis is a global health problem and one of the most common chronic conditions in children. Development of rhinoconjunctivitis depends on both genetic and environmental factors. Many studies have...

    Elisabeth Soegaard Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Carsten Bindslev-Jensen, Arne Høst, Charlotte Gotthard Mortz and Susanne Halken

    Clinical and Translational Allergy 2017 7:9

    Published on: 3 April 2017

  8. Meeting abstracts

    Abstracts from the Food Allergy and Anaphylaxis Meeting 2016

    Guillaume Pouessel, Claire Claverie, Julien Labreuche, Jean-Marie Renaudin, Aimée Dorkenoo, Mireille Eb, Anne Moneret-Vautrin, Antoine Deschildre, Stephane Leteurtre, Linus Grabenhenrich, Margitta Worm, Sabine Dölle, Kathrin Scherer, Isidor Hutteger, Morten Christensen, Carsten Bindslev-Jensen…

    Clinical and Translational Allergy 2017 7(Suppl 1):10

    Published on: 30 March 2017

    This article is part of a Supplement: Volume 7 Supplement 1

  9. Research

    The state of asthma epidemiology: an overview of systematic reviews and their quality

    Recently, we have published an overview of systematic reviews in allergy epidemiology and identified asthma as the most commonly reviewed allergic disease. Building on this work, we aimed to investigate the qu...

    Jon Genuneit, Annina M. Seibold, Christian J. Apfelbacher, George N. Konstantinou, Jennifer J. Koplin, Stefania La Grutta, Kirsty Logan, Carsten Flohr and Michael R. Perkin

    Clinical and Translational Allergy 2017 7:12

    Published on: 29 March 2017

  10. Brief communication

    Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children

    Cashew nut, pistachio nut and mango belong to the Anacardiaceae family and are botanically related. Therefore, cashew nut sensitised children are frequently advised to eliminate cashew nuts and pistachio nuts fro...

    J. P. M. van der Valk, R. el Bouche, R. Gerth van Wijk, H. de Groot, H. J. Wichers, A. E. J. Dubois and N. W. de Jong

    Clinical and Translational Allergy 2017 7:8

    Published on: 20 March 2017

  11. Review

    Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America

    Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare ...

    M. J. Torres, A. Romano, G. Celik, P. Demoly, D. A. Khan, E. Macy, M. Park, K. Blumenthal, W. Aberer, M. Castells, A. Barbaud, C. Mayorga and P. Bonadonna

    Clinical and Translational Allergy 2017 7:7

    Published on: 13 March 2017

  12. Research

    Galectin-3: an early predictive biomarker of modulation of airway remodeling in patients with severe asthma treated with omalizumab for 36 months

    Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined ...

    Anna Maria Riccio, Pierluigi Mauri, Laura De Ferrari, Rossana Rossi, Dario Di Silvestre, Louise Benazzi, Alessandra Chiappori, Roberto Walter Dal Negro, Claudio Micheletto and Giorgio Walter Canonica

    Clinical and Translational Allergy 2017 7:6

    Published on: 9 March 2017

  13. Erratum

    Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

    J. Bousquet, J. Farrell, G. Crooks, P. Hellings, E. H. Bel, M. Bewick, N. H. Chavannes, J. Correia de Sousa, A. A. Cruz, T. Haahtela, G. Joos, N. Khaltaev, J. Malva, A. Muraro, M. Nogues, S. Palkonen…

    Clinical and Translational Allergy 2017 7:5

    Published on: 20 February 2017

    The original article was published in Clinical and Translational Allergy 2016 6:29

  14. Research

    Effectiveness and safety of antihistamines up to fourfold or higher in treatment of chronic spontaneous urticaria

    Treatment with second-generation antihistamines is recommended in patients with chronic spontaneous urticaria (CSU). Some patients remain unresponsive even after up-dosing up to fourfold. Many third line treat...

    Mignon T. van den Elzen, Harmieke van Os-Medendorp, Imke van den Brink, Karin van den Hurk, Ouliana I. Kouznetsova, Alexander S. H. J. Lokin, Anna-Marijke Laheij-de Boer, Heike Röckmann, Carla A. F. M. Bruijnzeel-Koomen and André C. Knulst

    Clinical and Translational Allergy 2017 7:4

    Published on: 14 February 2017

  15. Research

    Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey

    Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases.

    Vanessa Garcia-Larsen, Rhonda Arthur, James F. Potts, Peter H. Howarth, Matti Ahlström, Tari Haahtela, Carlos Loureiro, Ana Todo Bom, Grzegorz Brożek, Joanna Makowska, Marek L. Kowalski, Trine Thilsing, Thomas Keil, Paolo M. Matricardi, Kjell Torén, Thibaut van Zele…

    Clinical and Translational Allergy 2017 7:3

    Published on: 27 January 2017

  16. Letter to the Editor

    Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

    We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. On...

    Nicolaj Brandt, Lene H. Garvey, Ulla Bindslev-Jensen, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen and Charlotte G. Mortz

    Clinical and Translational Allergy 2017 7:2

    Published on: 10 January 2017

  17. Review

    Looking forward to new targeted treatments for chronic spontaneous urticaria

    The introduction of omalizumab to the management of chronic spontaneous urticaria (CSU) has markedly improved the therapeutic possibilities for both, patients and physicians dealing with this disabling disease...

    Emek Kocatürk, Marcus Maurer, Martin Metz and Clive Grattan

    Clinical and Translational Allergy 2017 7:1

    Published on: 10 January 2017

    The Erratum to this article has been published in Clinical and Translational Allergy 2017 7:11

  18. Review

    ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

    The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2)...

    J. Bousquet, P. W. Hellings, I. Agache, A. Bedbrook, C. Bachert, K. C. Bergmann, M. Bewick, C. Bindslev-Jensen, S. Bosnic-Anticevitch, C. Bucca, D. P. Caimmi, P. A. M. Camargos, G. W. Canonica, T. Casale, N. H. Chavannes, A. A. Cruz…

    Clinical and Translational Allergy 2016 6:47

    Published on: 30 December 2016

  19. Brief communication

    Cross-reactive LTP sensitization in food-dependent exercise-induced urticaria/anaphylaxis: a pilot study of a component-resolved and in vitro depletion approach

    Challenge tests for food-dependent exercise-induced anaphylaxis (FDEIA) carry some risk and have a high rate of false negatives. Our aim was to explore the usefulness of an in vitro immunodepletion assay and a...

    Diana Margarida Gonçalves Solha Pereira da Silva, Teresa Maria Silva Vieira, Ana Maria Alves Pereira, André Miguel Afonso de Sousa Moreira and José Luís Dias Delgado

    Clinical and Translational Allergy 2016 6:46

    Published on: 22 December 2016

  20. Brief communication

    Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity

    Although total IgE levels have been proposed as a biomarker for disease severity in atopic dermatitis (AD) and are increased in the majority of AD patients, they do not correlate with disease severity during s...

    J. L. Thijs, K. Knipping, C. A. F. Bruijnzeel-Koomen, J. Garssen, M. S. de Bruin-Weller and D. J. Hijnen

    Clinical and Translational Allergy 2016 6:44

    Published on: 6 December 2016

  21. Editorial

    A mutually beneficial collaboration between the European Academy of Allergy and Clinical Immunology Junior Members and Clinical and Translational Allergy

    The European Academy of Allergy and Clinical Immunology (EAACI) Junior Members (JM) comprise the largest EAACI section with around 4000 clinicians and scientists under 35 years of age working in the field of a...

    Peter Valentin Tomazic, Anke Graessel, Diana Silva, Ibon Eguiluz-Gracia, George V. Guibas, Clive Grattan, Jean Bousquet and Olympia Tsilochristou

    Clinical and Translational Allergy 2016 6:43

    Published on: 1 December 2016

  22. Review

    Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies

    Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al...

    M. A. Calderon, P. Demoly, T. Casale, C. A. Akdis, C. Bachert, M. Bewick, B. M. Bilò, B. Bohle, S. Bonini, A. Bush, D. P. Caimmi, G. W. Canonica, V. Cardona, A. M. Chiriac, L. Cox, A. Custovic…

    Clinical and Translational Allergy 2016 6:41

    Published on: 23 November 2016

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