Table 4 Summary of the evidence for ‘efficacy of systemic steroids in CRSsNP in adults’
Study | Year | LOE (1a to 5) | Study design | Study groups | Clinical end-point efficacy | Conclusion |
|---|---|---|---|---|---|---|
Subramanian et al. | 2002 | 4 | Retrospective | CRS patients (23 CRSsNP and 17 CRSwNP) treated with 1 month antibiotics + intranasal steroids + prednisone tapered over 10 days (20 mg 2×/day for 5 days, 20 mg 1×/day for 5 days). Mostly adult patients (2 patients under 18) | Change in CT scores, symptom scores post-treatment. Time to relapse | Beneficial effect of multimodal therapy on scoring of CT, symptoms or both in 90% of all CRS patients, no specific subanalysis for CRSsNP. Beneficial effect continued beyond 8 weeks in 60% of patients. No subanalysis made for CRSsNP |
Lal et al. | 2009 | 4 | Retrospective | Adult CRS patients (23 CRSsNP and 17 CRSwNP) treated with antibiotics + intranasal steroids + intranasal decongestants + prednisone tapered over 12 days (60, 40, 20, 10 mg for 3 days each) | Complete endoscopic and symptomatic resolution of symptoms 2 months after start of treatment | Beneficial effect of treatment in 54.9% of CRSsNP |