From: Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
Global (n = 648) | Intermittent (n = 253) | Mild (n = 246) | Moderate (n = 101) | Severe (n = 48) | P value* | |
---|---|---|---|---|---|---|
Sex, n (%) | 0.316 | |||||
Male | 233 (34) | 90 (36) | 84 (34) | 38 (38) | 11 (23) | |
Female | 425 (66) | 163 (64) | 162 (66) | 62 (62) | 37 (77) | |
Age, years | 1.72e−12‡ | |||||
Median (IQ25–75) | 29 (20–38) | 27 (20–36) | 27 (19–35) | 34 (24–44) | 41 (34–53) | |
Smoker n (%) | 54 (8) | 24 (9.5) | 21 (8.5) | 9 (9) | 0 | 0.369 |
Obesity n (%) | 115 (18) | 46 (18.2) | 36 (14.9) | 19 (19.2) | 13 (27) | 0.221 |
Conjunctivitis n (%) | 107 (16.5) | 54 (21.3) | 40 (16.3) | 11 (11) | 2 (4.2) | 0.008201‡ |
Rhinitis n (%) | 640 (98.8) | 250 (98.8) | 244 (99.2) | 99 (99) | 47 (97.9) | 0.885 |
Polyposis n (%) | 17 (2.62) | 1 (0.8) | 2 (0.8) | 9 (9) | 4 (8.3) | 0.00013‡ |
Chronic sinusitis n (%) | 32 (4.94) | 11 (4.3) | 11 (4.5) | 8 (8) | 2 (4.2) | 0.519 |
Atopic dermatitis n (%) | 23 (3.55) | 12 (4.7) | 5 (2) | 5 (5) | 1 (2.1) | 0.295 |
Previous pneumonia n (%) | 5 (0.77) | 1 (0.4) | 2 (0.8) | 1 (1) | 1 (2.1) | 0.332 |
FEV1 (l) | 3.98e−22‡ | |||||
Median (IQ25–75) | 2.9 (2.5–3.4) | 3.1 (2.7–3.6) | 2.9 (2.6–3.5) | 2.6 (2.2–3.1) | 2.0 (1.7–2.5) | |
FEV1 (%) | 1.14e−24‡ | |||||
Median (IQ25–75) | 90 (81–100) | 95 (88–104) | 90.5 (84–98) | 78 (68–90) | 74 (60–81) | |
Feno (ppb) | 0.873 | |||||
Median (IQ25–75) | 40 (23–72) | 41 (23–73) | 41 (26–72) | 35.5 (19–69) | 38 (21–60) | |
Total IgE (IU/ml)§ | 0.0789 | |||||
Median (IQ25–75) | 255 (117–563) | 225 (111.5–533) | 274 (113–615) | 305 (124–711) | 213 (93–426) | |
IgE Dermatophagoides pteronyssinus | 0.0637 | |||||
Median (IQ25–75) | 42 (15–100) | 34 (13–99) | 51 (21–101) | 44 (16–100) | 42 (5.8–98) | |
IgE Dermatophagoides farinae | 0.119 | |||||
Median (IQ25–75) | 27 (11–79) | 21 (10–66) | 34 (12–81) | 26 (11–85) | 32 (5.7–78.8) | |
IgE Blomia tropicalis | 0.931 | |||||
Median (IQ25–75) | 7 (2.1–21) | 7 (2–19) | 6.8 (3–23) | 8.8 (2.1–20) | 6.9 (3–19) | |
IgE Lepidoglyphus destructor | 0.448 | |||||
Median (IQ25–75) | 2.4 (1–7) | 2.6 (0.9–6) | 2.1 (1–6) | 2.1 (1–11) | 4.1 (2–9) | |
IgE Tyrophagus putrescientae | 0.743 | |||||
Median (IQ25–75) | 2 (1–7.5) | 3 (1–7) | 2 (1–7) | 2 (1–8.5) | 3.1 (1–1.9) | |
IgE Acarus siro | 0.389 | |||||
Median (IQ25–75) | 2.6 (1–7) | 2.7 (0.9–7.5) | 2.4 (1–7) | 5 (1–9) | 1.3 (0.7–1.8) | |
IgA (mg/dL)§ | 0.00024‡ | |||||
Median (IQ25–75) | 217 (162–279) | 220.5 (164–292) | 205.5 (157–260) | 205.5 (161–271.5) | 268 (220–334) | |
Eosinophils (109/L)§ | 0.153 | |||||
Median (IQ25–75) | 0.3 (0.2–0.5) | 0.3 (0.2–0.5) | 0.3 (0.2–0.5) | 0.3 (0.2–0.5) | 0.3 (0.1–0.5) | |
Nasal cytology eosinophils (%) | 0.265 | |||||
Median (IQ25–75) | 37.5 (10–70) | 40 (10–70) | 40 (15–70) | 30 (5–50) | 40 (5–60) | |
AAT (mg/dL)§ | 0.945 | |||||
Median(IQ25–75) | 134 (118–154) | 135 (115–159) | 134 (118–154) | 133 (116–149) | 135 (119–144) |