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Table 2 Diagnosis of multi-morbidities associated with allergic rhinitis (AR)

From: Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report

Multi-morbidities of AR

Definitive medical history, symptoms and signs

Asthma

Ask about any history of cough, wheeze, shortness of breath, exercise-induced bronchospasm

Examine the chest for wheeze, hyperexpansion

Assess peak expiratory flows and spirometry in older children preferably with reversibility testing with beta-2 agonists

If in doubt, undertake an exercise, mannitol or methacholine challenge test or measure exhaled nitric oxide (FENO)

Conjunctivitis

Ask about a history of red, itchy, watery eyes, eye rubbing

Examine eyes

Rhinosinusitis

Ask about a history of nasal obstruction or discharge (purulent) with or without hyposmia, headache, facial pain or cough

Undertake nasendoscopy in older children

CT scan/sinus X-rays not recommended unless there are complications or failed therapy, unilateral symptoms or severe disease unresponsive to medical therapy

Otitis media with effusion (OME)/impaired hearing

Ask questions related to immune deficiency and/or recurrent infections

Ask about any speech and language delay, increasing volume of TV, shouting, poor concentration, failing performance at school, frustration, irritability

Examine the ears using a pneumatic otoscope if possible, and Weber and Rinne tests

Use tympanoscopy for evaluation of tympanic membrane and middle ear

Undertake tympanometry

Use a whisper test to screen otitis media with effusion and hearing loss

Use audiometry in older children—pure tones, speech

Obstructive sleep apnea and sleep problems

Enquire about any history of disturbed sleep, snoring, apnoea, tiredness, irritability

Assess nasal airway using spatula misting, nasal inspiratory peak flow, visual examination of nostrils and nasendoscopy in older children to view nasal airway and adenoids

Consider sleep study

Atopic dermatitis

Ask about skin symptoms of itching, redness, rash

Food allergy

Ask about symptoms related to food intake

Ask for oral allergy syndrome (OAS): Allergic reaction that occurs upon contact of the mouth and throat with raw fruits or vegetables which may be tolerated when cooked

Eosinophilic oesophagitis

Ask for symptoms related to esophageal dysfunction as solid food dysphagia, chest pain, heartburn and upper abdominal pain

Assess esophageal biopsies

Adenoid hypertrophy

Ask about nasal obstruction, open mouth breathing and snoring

Examine the face

Perform posterior rhinoscopy; nasal and nasopharyngeal rigid/flexible endoscopy

Olfactory dysfunction

Ask for olfactory dysfunction, hyposmia, anosmia

Evaluate nasal airway and smell function tests

Laryngitis, cough and vocal problems

Ask for symptoms including irritation in the throat, the sensation of difficult to shift mucus and cough

Examine throat and larynx, see vocal cords and arytenoids

Gastro esophageal reflux

Ask for symptoms of indigestion, regurgitation, cough

Examine throat and larynx

Fatigue and learning impairment

Ask about fatigue and learning impairment, school success

Ask about sleep quality, nasal obstruction and nasal discharge

Turbinate hypertrophy

Ask about nasal obstruction

Perform anterior rhinoscopy and nasal endoscopy, acoustic rhinometry pre and post decongestant shows whether mucosal lining or bony structure is responsible