Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back

Table 2 Well-defined HLA associations in DHR [28]

Drug	Syndrome	HLA allele	HLA carrier rate	NPV	PPV (%)	NNT
Abacavir	ABC HS	B*57:01 [31, 34]	5–8% Caucasian	100%	55	13
Allopurinol	SJS/TEN and DRESS/DIHS	B*58:01 [25]	9–11% Han Chinese 1–6% Caucasian	100% in Han Chinese	3	250
Carbamazepine	SJS/TEN	B*15:02 [12, 27, 28]	10–15% Han Chinese	100% in Han Chinese	3	1,000
Dapsone	DRESS/DIHS	B*13:01 [25]	28% Papuans, Australian aborigines; 2–20% Chinese; 1.5% Japanese; 1–12% Indian; 2–4% Southeast Asians	99.8%	7.8	84

NPV negative predictive value, PPV positive predictive value, NNT numbers needed to test (to prevent one case), ABC HS abacavir hypersensitivity syndrome.

ISSN: 2045-7022