Volume 4 Supplement 1

3rd Pediatric Allergy and Asthma Meeting (PAAM)

Open Access

O14 - Der p 10 as a minor allergen in children sensitised to house dust mites

  • Isabel Lafuente1,
  • Raquel Pina1,
  • Sonia Uixera1,
  • Rafael Calderon1,
  • Isidoro Cortell1,
  • Juan Lopez1,
  • Antonio Nieto1 and
  • Angel Mazon1
Clinical and Translational Allergy20144(Suppl 1):O14

https://doi.org/10.1186/2045-7022-4-S1-O14

Published: 28 February 2014

Objective

To assess the proportion of children with specific IgE to Der p 10 in children with sensitization to house dust mites (HDM).

Material and methods

We determined specific IgE (ImmunoCAP®, Thermo Fisher Scientific) to Der p 1, Der p 2 and Der p 10 simultaneously in children with symptoms of asthma and/or rhinoconjunctivitis who had positive skin tests to HDM. Values <0.35 kUA/L were considered negative.

Results

We studied 232 children (147 M/85 F) aged 1.25 - 16.7 years. Negative results were found in 50 (21.6%) with Der p 1, 53 (22.8%) with Der p 2, 208 (89.7%) with Der p 10, and 29 with all three (12.5%). There were 24 patients with positive IgE to Der p 10: three of these had IgE values of 6.1 to 11 kUA/L to Der p 10 and negative results to Der p 1 and 2 (0.1 to 0.18), three had much higher IgE to Der p 10 (79.9 to >100) than to Der p 1 or 2 (0,58 to 24.2), and one slightly higher IgE to Der p 10 (2.8) than to Der p 1 or 2 (0.8 and 1.19). The rest of the patients had clearly lower IgE to Der p 10.

Conclusion

About 10% of patients sensitized to HDM had specific IgE to Der p 10. Sensitization to Der p 10 without sensitization to major allergens Der p 1 and Der p 2 appeared in 1.3% of patients, and serologically more relevant sensitization to Der p 10 in an additional 1.3% of patients. This should be considered when prescribing immunotherapy, as Der p 10 is not standardized in current vaccines.

Authors’ Affiliations

(1)
Unit of Pediatric Allergy and Pneumology Hospital La Fe

Copyright

© Lafuente et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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