Table 3 Difference in cytokine secretion by ex vivo restimulated PBMC isolated from subjects post- minus pre-consumption of either L. paracasei NCC2461 or a blend of L. acidophilus SD5221 and B. lactis SD5219

IL5 (pg/ml)

NS

29

0.00

0.77

0.18

−69.61

6.96

0.92

MM

29

26.58

83.51

19.44

−79.91

462.69

0.09

GR

29

85.51

150.53

35.03

−144.70

529.87

0.005

IL8 (pg/ml)

NS

29

3328

20686

4814

−137069

51061

0.45

MM

29

51074

177356

41277

−331659

489670

0.41

GR

29

85702

156506

36424

−370412

1328885

0.004

IL10 (pg/ml)

NS

29

0.00

0.46

0.11

−1.04

2.48

0.89

MM

29

1.80

4.80

1.12

−5.93

16.14

0.01

GR

29

3.03

6.63

1.54

−11.60

25.20

0.008

IL13 (pg/ml)

NS

29

0.00

4.52

1.05

−87.11

116.31

0.97

MM

29

49.93

288.58

67.16

−1000.90

1080.11

0.09

GR

29

266.00

332.54

77.39

−466.57

908.99

0.001

IFN-γ (pg/ml)

NS

29

0.00

0.00

0.00

−106.58

169.48

0.86

MM

29

1644.34

8456.16

1868.04

−30350.99

43924.50

0.15

GR

29

−165.66

1495.68

348.10

−6365.44

10243.64

0.36

Blend of L. acidophilus SD5221 and B. lactis SD5219 treatment

Allergen n n

Median

Rob. SD

SE median

Min.

Max.

p -value

IL5 (pg/ml)

NS

31

0.00

0.83

0.19

−5.51

17.17

0.29

MM

31

0.23

77.11

17.36

−378.76

221.79

0.98

GR

31

29.36

170.38

38.35

−674.14

1686.96

0.20

IL8 (pg/ml)

NS

31

2353

22598

5087

−240155

73699

0.84

MM

31

−26620

166240

37421

−353181

1134834

0.85

GR

31

−7132

153404

34532

−1326885

300638

0.96

IL10 (pg/ml)

NS

31

0.00

0.41

0.09

−11.18

3.57

0.42

MM

31

0.84

6.02

1.36

−13.71

11.87

0.58

GR

31

0.60

5.95

1.34

−14.84

17.89

0.75

IL13 (pg/ml)

NS

31

0.00

0.794

0.18

−10.672

70.676

0.04

MM

31

59.10

322.66

72.63

−1023.04

4155.62

0.42

GR

31

151.92

374.60

84

−721.54

924.79

0.14

IFN-γ (pg/ml)

NS

31

0.00

0.46

0.10

−60.03

252.65

0.41

MM

31

−365.81

9372.17

2109.69

−45256.46

21604.04

0.59

GR

31

−200.91

1261.78

284.03

−8287.66

3864.57

0.59