|
CpG
|
CHR
|
Great annotation (distance to TSS)
|
Discovery
|
Replication-EGEA
|
Replication-Lifelines
|
Meta-analysis
|
|---|
|
Coef
|
SE
|
P
|
N
|
Coef
|
SE
|
P
|
Nb
|
Coef
|
SE
|
P
|
N
|
P.meta
|
Direction
|
|---|
|
cg10125195
|
12
|
LACRT (+ 133)
|
1.32E−02
|
2.30E−03
|
9.03E−09
|
72
|
1.098
|
0.748
|
0.142
|
80 (69/11)
|
2.73E−04
|
3.56E−03
|
0.939
|
124
|
1.58E−04
|
+ + +
|
|
cg12713893
|
18
|
SNRPD1 (+ 44)
|
4.64E−03
|
8.63E−04
|
7.52E−08
|
72
|
7.127
|
5.359
|
0.184
|
120 (106/14)
|
4.19E−04
|
1.11E−03
|
0.705
|
124
|
2.90E−04
|
+ + +
|
|
cg15404785
|
14
|
TRMT5 (− 279,717); TMEM30B (+ 20,765)
|
− 3.09E−02
|
5.17E−03
|
2.43E−09
|
72
|
0.423
|
0.150
|
0.005
|
105 (93/12)
|
− 4.93E−03
|
6.11E−03
|
0.420
|
124
|
7.58E−02
|
− + −
|
|
cg27252019
|
17
|
MKS1 (+ 550)
|
− 3.86E−02
|
7.24E−03
|
1.01E−07
|
72
|
− 0.033
|
0.269
|
0.902
|
91 (80/11)
|
5.71E−03
|
1.01E−02
|
0.572
|
124
|
1.80E−02
|
– +
|
|
cg06185924
|
10
|
ACBD5 (− 42)
|
1.10E−02
|
2.06E−03
|
9.36E−08
|
72
|
NA
|
NA
|
NA
|
106 (92/14)
|
− 4.72E−03
|
2.33E−03
|
0.043
|
124
|
1.05E−01
|
+ NA−
|
|
cg13378519a
|
1
|
PEX11B (+ 18)
|
− 5.99E−03
|
1.07E−03
|
2.43E−08
|
72
|
NA
|
NA
|
NA
|
119 (105/15)
|
− 1.08E−02
|
2.61E−03
|
3.57E-05
|
124
|
2.58E−11
|
−NA−
|
|
cg17900884
|
1
|
ICMT (− 91)
|
3.58E−03
|
6.28E−04
|
1.15E−08
|
72
|
NA
|
NA
|
NA
|
114 (101/13)
|
− 1.78E−04
|
9.86E−04
|
0.857
|
124
|
9.16E−04
|
+ NA−
|
- P.meta: the P value of meta-analysis of results from discovery, EGEA and Lifelines by using weighted Z-score method
- Direction: the direction of regression coefficient in discovery, EGEA and Lifelines
- NA: the result for this probe was not available in EGEA
- aThe CpG site was replicated with meta P value < 1.14 × 10–7
- bN (persA/ClinR), N varies from one CpG to another because of the methylC-capture sequencing method used and QC criteria in EGEA
