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Table 2 Seven genome-wide significant CpG sites (P value < 1.14 × 10–7) of ClinR in relation to methylation in whole blood

From: Epigenome-wide association study identifies DNA methylation markers for asthma remission in whole blood and nasal epithelium

CpG CHR Great annotation (distance to TSS) Discovery Replication-EGEA Replication-Lifelines Meta-analysis
Coef SE P N Coef SE P Nb Coef SE P N P.meta Direction
cg10125195 12 LACRT (+ 133) 1.32E−02 2.30E−03 9.03E−09 72 1.098 0.748 0.142 80 (69/11) 2.73E−04 3.56E−03 0.939 124 1.58E−04  +  +  + 
cg12713893 18 SNRPD1 (+ 44) 4.64E−03 8.63E−04 7.52E−08 72 7.127 5.359 0.184 120 (106/14) 4.19E−04 1.11E−03 0.705 124 2.90E−04  +  +  + 
cg15404785 14 TRMT5 (− 279,717); TMEM30B (+ 20,765) − 3.09E−02 5.17E−03 2.43E−09 72 0.423 0.150 0.005 105 (93/12) − 4.93E−03 6.11E−03 0.420 124 7.58E−02 − + −
cg27252019 17 MKS1 (+ 550) − 3.86E−02 7.24E−03 1.01E−07 72 − 0.033 0.269 0.902 91 (80/11) 5.71E−03 1.01E−02 0.572 124 1.80E−02 – + 
cg06185924 10 ACBD5 (− 42) 1.10E−02 2.06E−03 9.36E−08 72 NA NA NA 106 (92/14) − 4.72E−03 2.33E−03 0.043 124 1.05E−01  + NA−
cg13378519a 1 PEX11B (+ 18) − 5.99E−03 1.07E−03 2.43E−08 72 NA NA NA 119 (105/15) − 1.08E−02 2.61E−03 3.57E-05 124 2.58E−11 −NA−
cg17900884 1 ICMT (− 91) 3.58E−03 6.28E−04 1.15E−08 72 NA NA NA 114 (101/13) − 1.78E−04 9.86E−04 0.857 124 9.16E−04  + NA−
  1. P.meta: the P value of meta-analysis of results from discovery, EGEA and Lifelines by using weighted Z-score method
  2. Direction: the direction of regression coefficient in discovery, EGEA and Lifelines
  3. NA: the result for this probe was not available in EGEA
  4. aThe CpG site was replicated with meta P value < 1.14 × 10–7
  5. bN (persA/ClinR), N varies from one CpG to another because of the methylC-capture sequencing method used and QC criteria in EGEA
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