Epigenome-wide association study identifies DNA methylation markers for asthma remission in whole blood and nasal epithelium

Table 2 Seven genome-wide significant CpG sites (P value < 1.14 × 10^–7) of ClinR in relation to methylation in whole blood

CpG	CHR	Great annotation (distance to TSS)	Discovery				Replication-EGEA				Replication-Lifelines				Meta-analysis
CpG	CHR	Great annotation (distance to TSS)	Coef	SE	P	N	Coef	SE	P	N^b	Coef	SE	P	N	P.meta	Direction
cg10125195	12	LACRT (+ 133)	1.32E−02	2.30E−03	9.03E−09	72	1.098	0.748	0.142	80 (69/11)	2.73E−04	3.56E−03	0.939	124	1.58E−04	+ + +
cg12713893	18	SNRPD1 (+ 44)	4.64E−03	8.63E−04	7.52E−08	72	7.127	5.359	0.184	120 (106/14)	4.19E−04	1.11E−03	0.705	124	2.90E−04	+ + +
cg15404785	14	TRMT5 (− 279,717); TMEM30B (+ 20,765)	− 3.09E−02	5.17E−03	2.43E−09	72	0.423	0.150	0.005	105 (93/12)	− 4.93E−03	6.11E−03	0.420	124	7.58E−02	− + −
cg27252019	17	MKS1 (+ 550)	− 3.86E−02	7.24E−03	1.01E−07	72	− 0.033	0.269	0.902	91 (80/11)	5.71E−03	1.01E−02	0.572	124	1.80E−02	– +
cg06185924	10	ACBD5 (− 42)	1.10E−02	2.06E−03	9.36E−08	72	NA	NA	NA	106 (92/14)	− 4.72E−03	2.33E−03	0.043	124	1.05E−01	+ NA−
cg13378519^a	1	PEX11B (+ 18)	− 5.99E−03	1.07E−03	2.43E−08	72	NA	NA	NA	119 (105/15)	− 1.08E−02	2.61E−03	3.57E-05	124	2.58E−11	−NA−
cg17900884	1	ICMT (− 91)	3.58E−03	6.28E−04	1.15E−08	72	NA	NA	NA	114 (101/13)	− 1.78E−04	9.86E−04	0.857	124	9.16E−04	+ NA−

P.meta: the P value of meta-analysis of results from discovery, EGEA and Lifelines by using weighted Z-score method
Direction: the direction of regression coefficient in discovery, EGEA and Lifelines
NA: the result for this probe was not available in EGEA
^aThe CpG site was replicated with meta P value < 1.14 × 10^–7
^bN (persA/ClinR), N varies from one CpG to another because of the methylC-capture sequencing method used and QC criteria in EGEA

ISSN: 2045-7022