TY - JOUR AU - Ding, Yuanyuan AU - Zhang, Tao AU - Liu, Rui AU - Che, Delu AU - Wang, Nan AU - He, Langchong PY - 2020 DA - 2020/12/09 TI - A novel ELISA method to determine human MrgX2 in chronic urticaria JO - Clinical and Translational Allergy SP - 61 VL - 10 IS - 1 AB - Mas-related G-protein coupled receptor member X2 (MrgX2) directly mediates drug-induced pseudo allergic reactions. Skin mast cell MrgX2 is upregulated in severe chronic urticaria (CU). Mast cells and leukocytes are key effector cells in allergic reactions and undergo degranulation upon stimulation. It is unknown whether circulating MrgX2 expression can be detected occurs in the whole blood of CU patients and reflects pseudo-allergic reaction. There is no effective method for its detection. Therefore, an enzyme-linked immuno-sorbent assay (ELISA) for MrgX2 was developed. SN - 2045-7022 UR - https://doi.org/10.1186/s13601-020-00361-8 DO - 10.1186/s13601-020-00361-8 ID - Ding2020 ER -