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Table 1 Patient characteristics

From: Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS)

  Total
N = 46
Demographics
 Age (at time of DRESS) 52.0 (38.3; 65.0)
 Gender (female) 23 (50.0%)
Clinical
 Exanthema (n) 46 (100.0%)
 Centro-facial oedema (n) 15 (32.6%)
 Fever > 38.0 ºC (n) 35 (76.1%)
 Eosinophilia > 0.5G/L (n) 40 (87.0%)
 Eosinophilia, mean (G/L) 3.0 ± 3.5
 Atypical lymphocytes (n) 20 (43.5%)
 Hepatitis (n) 39 (84.8%)
 Lymphadenopathy (n) 12 (26.1%)
 Renal involvement (n) 12 (26.1%)
 Pulmonary involvement (n) 2 (4.3%)
 Cardiac involvement (n) 2 (4.3%)
 Cytopenia (n) 6 (13.0%)
 Other organ involvementa 7 (15.2%)
 Number of organs involved (mean) 1.4 ± 0.7
 Viral reactivation, detected in 8/13 (n) 8 (17.4%)
 Lethal outcome (n)b 0 (0.0%)
 DRESS with MDH 13 (28.1%)
Latency period (days) 19.0 (9.3; 27.8)
Comorbidities
 Autoimmune disease (n) 8 (17.4%)
 Renal insufficiency (n) 6 (13.0%)
 Infectious disease (n)c 15 (32.6%)
 Cardiac disease (n) 9 (19.6%)
 Epilepsy (n) 8 (17.4%)
 Neoplastic disease (n) 7 (15.2%)
  1. Values are median and interquartile ranges (IQR) for continuous variables. Categorical variables reported as n (%)
  2. Multiple drug hypersensitivity syndrome (MDH), drug reaction with eosinophilia and systemic symptoms (DRESS)
  3. aPancreatitis, gastrointestinal involvement, neurological involvement, myositis
  4. b2 cases with lethal DRESS outcome were excluded because of missing skin test and lymphocyte transformation test (see Fig. 1)
  5. cRefers to the period of one month before the onset of DRESS: 5 × pneumonia, 2 × acute prostatitis, 2 × endocarditis, 1 × septic arthritis, 1 × osteomyelitis, 1 × acute cholecystitis, 1 × cellulitis, 1 × acute toxoplasmosis, 1 × acute rhinosinusitis