Table 1 Patient characteristics
From: Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS)
Total | |
|---|---|
N = 46 | |
Demographics | |
Age (at time of DRESS) | 52.0 (38.3; 65.0) |
Gender (female) | 23 (50.0%) |
Clinical | |
Exanthema (n) | 46 (100.0%) |
Centro-facial oedema (n) | 15 (32.6%) |
Fever > 38.0 ºC (n) | 35 (76.1%) |
Eosinophilia > 0.5G/L (n) | 40 (87.0%) |
Eosinophilia, mean (G/L) | 3.0 ± 3.5 |
Atypical lymphocytes (n) | 20 (43.5%) |
Hepatitis (n) | 39 (84.8%) |
Lymphadenopathy (n) | 12 (26.1%) |
Renal involvement (n) | 12 (26.1%) |
Pulmonary involvement (n) | 2 (4.3%) |
Cardiac involvement (n) | 2 (4.3%) |
Cytopenia (n) | 6 (13.0%) |
Other organ involvementa | 7 (15.2%) |
Number of organs involved (mean) | 1.4 ± 0.7 |
Viral reactivation, detected in 8/13 (n) | 8 (17.4%) |
Lethal outcome (n)b | 0 (0.0%) |
DRESS with MDH | 13 (28.1%) |
Latency period (days) | 19.0 (9.3; 27.8) |
Comorbidities | |
Autoimmune disease (n) | 8 (17.4%) |
Renal insufficiency (n) | 6 (13.0%) |
Infectious disease (n)c | 15 (32.6%) |
Cardiac disease (n) | 9 (19.6%) |
Epilepsy (n) | 8 (17.4%) |
Neoplastic disease (n) | 7 (15.2%) |