Fig. 4

Functional annotation of the genes corresponding to the SNPs that were significantly associated with asthma/AR in GWASs. We used the whole list of SNPs (Ensemble codes) shown in the Additional file 1: Table S1. Of these, only SNPs that were connected to protein coding genes were used in this analysis, and only one unique gene associated with one or several SNPs were used. Noncoding genes related to these asthma/AR -associated SNPs were excluded in functional annotation. The total number of genes of this functional annotation was 155 genes. a Gene ontology (GO) categories (functional protein categories) that were enriched. b Gene function network interaction of the GO-categories. The network interaction shows strong interaction between the GO-categories and indicating regulation functions between each other. c Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched among 155 genes. Shades of blue and red indicate significance of the enrichment (all were significant at level p < 0.05), and the size of the dot represents gene count. X-axis represents the number of genes belonging to the particular category / total number of observed genes (N = 155)