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Fig. 1 | Clinical and Translational Allergy

Fig. 1

From: Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa

Fig. 1

Flow chart of the study. GWASs were searched from databases (https://www.ebi.ac.uk/gwas/) and a list and database of SNPs associating significantly (p < 10–8) with asthma, AR and CRS was formed in 1/2018. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation analysis was performed for protein coding genes connected to SNPs. Airway epithelial expression of genes and corresponding proteins were evaluated by using Gene Cards, Human Protein Atlas (HPA), and literature search from PubMed. Other potential airway functions of the selected set of genes were evaluated from database /literature search. Abbreviations: AR allergic rhinitis, CRS chronic rhinosinusitis, GO Gene Ontology, GWAS genome-wide association study, HPA Human Protein Atlas, KEGG Kyoto Encyclopedia of Genes and Genomes, SNP single nucleotide polymorphism, TPM Transcripts Per Million

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