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Table 2 Targets of IgE autoantibodies in atopic dermatitis

From: IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis

Human autoantigens Synonym Molecular weight (kDa) Prevalence (% of autoreactive AD patients) Healthy controls Description References
Actin α ACTA2 42 15.5% (11/71) 0% (0/24) Alpha smooth muscle actin Zeller et al. [36]
Autologous sweat MGL_1304 29 84.4% (56/66)*
77.0% (47/61)**
5–27% (children)
29–65% (adults)
11.1% (3/27)*
8.7% (4/46)**
Product from Malassezia globosa, sharing homologs with other Malassezia species, but no cross-antigenicity with human proteins Hide et al. [54]
Tanaka et al. [55]
Glatz et al. [107]
Cytotoxic T-lymphocyte (CTL)-directed epitopes: SART2161
SART3109
SART3315
ART475
CypB84
CypB91
CypB
21 2.5% (1/40)
37.5% (15/40)
15% (6/40)
10% (4/40)
27.5% (11/40)
17.5% (7/40)
9.2% (6/71)
4.9% (2/41)
29.3% (12/41)
17.1% (7/41)
12.2% (5/41)
29.3% (12/41)
31.7% (13/41)
0% (0/24)
SART, ART4, CypB; highly expressed in proliferating cells
SART; squamous cell carcinoma antigen. Tumor associated antigen recognized by CTL
ART4; Adenocarcinoma antigens recognized by T cells 4
CypB; cyclophilin B, identified in all cell types in the endoplasmic reticulum, nucleus and in serum. Associated with progression of inflammatory diseases
Kawamoto et al. [30]
Zeller et al. [36]
Dense fine speckles (DFS70)/Lens epithelium derived growth factor (LEDGF)   70 15% (9/61)
62.5% (10/16)
0% (0/20)
0% (0/1)
Survival factor, growth factor, HIV-transporter, nuclear antigen Watanabe et al. [31]
Ochs et al. [57]
eIF6   27 25.4% (19/71) 0% (0/24) Eukaryotic translation initiation factor 6, nuclear and ribosomal protein Zeller et al. [36]
Epidermal keratinocytes    37% (10/27) 0% (0/6)   Kortekangas-Savolainen et al. [33]
Epidermis    22% (12/54) 0% (0/138)   Altrichter et al. 35]
Epithelial cell line A431   25–97 43.1% (22/51)
60% (12/20)
91.7% (11/12)
17% (9/54)
72.7% (8/11)
23% (40/174)
0% (0/1)
0% (0/2)
0% (0/6)
0% (0/138)
0% (0/26)
  Natter et al. [19]
Valenta et al. [17]
Aichberger et al. [37]
Altrichter et al. [35]
Mittermann et al. [38]
Mothes et al. [20]
HLA-DR   24 8.7% (7/71) 0% (0/24) Human leukocyte antigen, expressed on Langerhans cells, macrophages, keratinocytes and dendritic cells Zeller et al. [36]
Hom s 1 SART-1 55–60    Cytoplasmatic and nuclear protein, SART1 almost identical sequence homology with Hom s1 Valenta et al. [18]
Hom s 2 α-NAC 23.2 27.3% (3/11)   Nascent polypeptide-associated complex, subunit α. Regulation of gene transcription Mittermann et al. [38]
Mossabeb et al. [108]
Hom s 3 BCL7B 20.1    Sequence identity with intracellular oncoprotein BCL7B. Positive regulator of apoptosis, maintenance of nuclear structure, stem cell differentiation Natter et al. [19]
Hom s 4 MICU1, CALC 54 16.7% (2/12) 0% (0/6) Basic protein which belongs to subfamily of calcium-binding proteins Aichberger et al. [37]
Hom s 5 Cytokeratin 6A, K6A, KRT6D 56–70    Keratin type II cytoskeletal 6A. Structural constituent of cytoskeleton Natter et al. [19]
Human manganese superoxide dismutase (hMnSOD) Asp f6 22 42% (29/69)
14.8% (4/27)
17,6% (adults, 3/17)*
10% (children, 1/10)*
0% (0/5)
0% 0/27)
0% (0/17)*
0% (0/10)*
Nuclear-encoded enzyme, located in mitochondria. Cross reactivity with Mala s 11 and Hev b 10 Schmid-Grendelmeier et al. [34]
Guarneri et al. [109]
Vilhelmsson et al. [110]
Andersson et al. [111]
Human thioredoxins (hTrx)   12 5% (3/61)
23.4% (16/71)
0% (0/20)
0% (0/24)
Small intracellular redox proteins involved in many important biological processes. 45% identity with Mala s13 Watanabe et al. [31]
Zeller et al. [36]
Schmid-Grendelmeieret al. [8]
Limacher et al. [66]
IgE, CH3 and CH4 domains    Unknown (n = 19 AD) Unknown (n = 13 HC)   Czech W et al. [112]
Ribosomal protein P2 RPLP2, Asp f8     Ribosomal phosphoprotein with a role in the elongation step of protein synthesis Mayer et al. [113]
RP1 MAPRE2 39 29.0% (21/71) 0% (0/24) Microtubule polymerization and stabilizing function Zeller et al. [36]
Tubulin α 1a TUBA1a 50 21.7% (14/71) 0% (0/24) Formation of microtubules for cytoskeletal structure Zeller et al. [36]
  1. * Investigated using skin prick test, not specific auto-IgE
  2. ** Investigated using histamine release from basophils