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Table 1 Prevalence of autoreactivity in patients with atopic dermatitis categorized by age

From: IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis

Patients with atopic dermatitis Severity of AD/population Prevalence of IgE autoreactivity in AD Prevalence of IgE autoreactivity in control subjects References
Children 0–1 year Mild–severe 20.0% (1/5) / Natter et al. [19]
Moderate–severe 15.0% (25/60) / Mothes et al. [20]
Children 2–13 years Mild–severe 16.7% (1/6) / Natter et al. [19]
Moderate–severe 80.0% (16/20) / Mothes et al. [20]
Adolescents 14–23 years Mild–severe 63.6% (7/11) / Natter et al. [19]
EASI: 10–39.4 50.0% (2/4) / Mitterman et al. [38]
Adults ≥ 24 years / 60.0% (12/20) 0.0% (0/2) Valenta et al. [17]
Mild–severe 44.8% (13/29) / Natter et al. [19]
/ 62.5% (10/16) 0% (0/1) Ochs et al. [57]
/ 2.5% (1/40) SART2161 4.9% (2/41) SART2161 Kawamoto et al. [30]
/ 37.5% (15/40) SART109 29.3% (12/41) SART109  
/ 15% (6/40) SART315 17.1% (7/41) SART315  
/ 27.5% (11/40) CypB84 29.3% (12/41) CypB84  
/ 17.5% (7/40) CypB91 31.7% (13/41) CypB91  
/ 10% (4/40) ART475 12.2% (5/41) ART475 Kinaciyan et al. [53]
Mild 100.0% (1/1) / Kortekangas-Savolainen [33]
/ 37.0% (10/27) / Aichberger et al. [37]
/ 91.7% (11/12) 0.0% (0/6) Mothes et al. [20]
/ 23.0% (40/174) / Schmid-Grendelmeier et al. [34]
EASI: 0.6–39.4 42.0% (29/69) / Tanaka et al. [55]
Mild–severe 77.0% (47/61) 8.7% (4/46) Mitterman et al. [38]
EASI: 4.4–59.8 85.7% (6/7) 0.0% (0/12) Altrichter et al. [35]
EASI: 0.6–39.4 28.0% (54/192) / Zeller et al. [36]
SCORAD: 21.93–71.36 71.8% (51/71) 0.0% (0/36) Watanabe et al. [31]
/ 14.8% (9/61) / Aichberger et al. [37]
/ 91.7% (11/12) 0.0% (0/6) Lucae et al. [91]
Moderate–severe 100% (4/4) / Roesner et al. [106]
/ 91.7% (11/12) /  
  1. Percentage of IgE autoreactivity in atopic dermatitis with the severity of the disease compared with healthy subjects, subdivided into children 0–1 year, 2–13 years, adolescents and adults
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