Skip to main content

Table 2 Definition of different total serum IgE levels cutoffs

From: AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

IgE deficiency
Ultra-low/absent total serum IgE levels (kU/L) IgE < 2.5
Normal total serum IgE levels (kU/L)
2.5 ≥ IgE < 100
High total serum IgE levels (kU/L)
100 ≥ IgE < 1,000
Very high total serum IgE levels (kU/L)
1,000 ≥ IgE < 10,000
Extremely high total serum IgE levels (kU/L)
IgE ≥ 10,000
Very low or absent IgE levels may be found in patients with allergic rhinitis-, chronic sinusitis-like symptoms and asthma [32, 36, 37, 58] Cannot exclude atopic/allergic or parasitic conditions Biomarker for atopy/allergy [29, 44, 45, 53, 55], parasitosis [71,72,73]
Might potentially be used as a marker for higher cancer susceptibility [32,33,34] Some patients with normal IgE levels may have higher rates of malignancy [18, 20] In general, elevated IgE levels are associated with lower rates and risk for malignancy [17, 20, 21, 142]. Very high and extremely high total serum IgE levels are seen in certain malignancies such as lymphoma [146] and IgE myeloma [147]
May be a sensitive and specific marker for CVID (Common Variable Immunodeficiency) when there is high suspicion for primary humoral deficiency [38] Cannot exclude immunodeficiency Elevated IgE levels may raise suspicion for certain immunodeficiencies in appropriate patients (e.g. HyperIgE syndrome (HIES), Wiskott-Aldrich syndrome; immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX); Omenn syndrome; Atypical complete DiGeorge syndrome) [35, 83, 86]