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Table 3 Adverse Events

From: Epinephrine delivery via EpiPen® Auto-Injector or manual syringe across participants with a wide range of skin-to-muscle distances

 Mid-AL thighDistal-AL thigh
Epinephrine via EpiPen (N = 35)Epinephrine via IM syringe (N = 35)Saline via IM syringe (N = 35)Epinephrine via EpiPen (n = 23)
Total AEs, n2725715
AEs considered related to treatment (> 3% in any treatment group), n (%)a
Palpitations6 (17.1)4 (11.4)07 (30.4)
Feeling abnormal4 (11.4)2 (5.7)02 (8.7)
Feeling hot3 (8.6)1 (2.9)00
Tremor3 (8.6)1 (2.9)01 (4.3)
Headache1 (2.9)2 (5.7)1 (2.9)0
Limb discomfort1 (2.9)1 (2.9)01 (4.3)
Myalgiab02 (5.7)00
  1. AE adverse event, AL anterolateral, EpiPen EpiPen Auto-Injector, IM intramuscular
  2. aAEs are listed in order of incidence
  3. bMyalgia was reported only in thigh muscle