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Table 9 Summary of the evidence for ‘efficacy of systemic steroids in sinonasal disease + concomitant asthma

From: Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

Study LOE (1a to 5) Study design Study groups Clinical endpoints efficacy Conclusion
Ikeda et al. [99] 3 Prospective RCT Adult CRSwNP and CRSsNP patients undergoing ESS 1. Sinonasal and pulmonary symptoms
2. Systemic GCS need
1. Improvement of FEV1
2. No significant changes in systemic GCS need
  1. RCT randomized controlled trial, CRS chronic rhinosinusitis, CRSsNP chronic rhinosinusitis without nasal polyps, CRS chronic rhinosinusitis, CRSwNP chronic rhinosinusitis with nasal polyps, GCS glucocorticosteroids