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Table 4 Summary of the evidence for ‘efficacy of systemic steroids in CRSsNP in adults’

From: Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

Study Year LOE (1a to 5) Study design Study groups Clinical end-point efficacy Conclusion
Subramanian et al. 2002 4 Retrospective CRS patients (23 CRSsNP and 17 CRSwNP) treated with 1 month antibiotics + intranasal steroids + prednisone tapered over 10 days (20 mg 2×/day for 5 days, 20 mg 1×/day for 5 days). Mostly adult patients (2 patients under 18) Change in CT scores, symptom scores post-treatment. Time to relapse Beneficial effect of multimodal therapy on scoring of CT, symptoms or both in 90% of all CRS patients, no specific subanalysis for CRSsNP. Beneficial effect continued beyond 8 weeks in 60% of patients. No subanalysis made for CRSsNP
Lal et al. 2009 4 Retrospective Adult CRS patients (23 CRSsNP and 17 CRSwNP) treated with antibiotics + intranasal steroids + intranasal decongestants + prednisone tapered over 12 days (60, 40, 20, 10 mg for 3 days each) Complete endoscopic and symptomatic resolution of symptoms 2 months after start of treatment Beneficial effect of treatment in 54.9% of CRSsNP
  1. CRS chronic rhinosinusitis, CRSsNP chronic rhinosinusitis without nasal polyps, CRSwNP chronic rhinosinusitis with nasal polyps