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Table 1 American Academy of Pediatrics defined strategy for recommendation development [9]

From: Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper

Evidence quality

Preponderance of benefit over harm

Balance of benefit and harm

Preponderance of harm over benefit

A. Well-designed RCTs

Strong recommendation

Option

Strong recommendation against

B. RCT’s with minor limitations; overwhelming consistent evidence from observational studies

Recommendation

C. Observational studies (case–control and cohort design)

Recommendation against

D. Expert opinion; case reports; reasoning from first principles

Option

No recommendation

  1. RCT randomized controlled trial