Rhinovirus species and tonsillar immune responses

Table 3 Cytokine or transcription factor expression

Cytokine or transcription factor	RV-A n = 16	RV-B n = 12	RV-C n = 14	P value univariate	P value multivariate	Adjustments
Th₁ -type
IFN-γ	71* (27, 104)	58 (34, 72)	72 (33, 98)	0.99	0.61	Spring
Tbet	72 (27, 309)	33 (15, 60)	40 (15, 70)	0.082	0.056	Respiratory symptoms, spring
Th₂ -type
IL-13	0.40 (0.018, 5.0)	0.37 (0.020, 3.4)	1.8 (0.36, 7.6)	0.14	0.14	–
GATA3	31 (13, 50)	20 (6.2, 33)	21 (12, 37)	0.36	0.98	Spring
Th₁₇ -type
IL-17	15 (9.1, 26)	14 (3.8, 26)	8.0 (4.0, 14)	0.37	0.36	Age
RORC2	22 (9.7, 71)	18 (7.2, 29)	14 (6.2, 25)	0.31	0.025	Respiratory symptoms
Treg -type
IL-10	55 (32, 84)	40 (14, 62)	33 (22, 74)	0.34	0.96	Age, spring
IL-37	0.38 (0.14, 0.50)	0.22** (0.14, 0.34)	0.27 (0.14, 0.34)	0.64	0.11	Respiratory symptoms
FOXP3	56 (19, 107)	33 (13, 89)	29 (16, 88)	0.47	0.12	Rhinitis
TGF-β	146 (94, 185)	192 (108, 252)	139 (102, 187)	0.49	0.49	–
Type I/III interferons
IFN-α	5.8 (0, 44)	0.37** (0.33, 38)	22 (2.9, 78)	0.23	0.045	Respiratory symptoms
IFN-β	15 (3.3, 81)	4.9 (2.2, 68)	61 (7.7, 116)	0.30	0.30	–
IL-28	25* (1.4, 88)	9.7 (1.4, 62)	32 (13, 109)	0.41	0.41	–
IL-29	5.9 (1.3, 35)	3.1 (1.3, 22)	11 (4.4, 40)	0.53	0.53	–

IFN interferon, Tbet T-box transcription factor, IL interleukin, GATA3 GATA-binding factor 3, RORC RAR-related orphan receptor C, FOXP forkhead box protein, TGF tumour growth factor, Th T helper cell, Treg T regulatory cell
Values are arbitrary units × 10⁴ relative to EF1α
Data are expressed as median (interquartile range)
Adjustments are selected backward stepwise from significant differences between groups (sex, rhinitis on the operation day, any respiratory symptoms on the operation day, operation made spring, operation made fall) and age
*n = 15
**n = 11

ISSN: 2045-7022