Fig. 1

Symptom score evolution over time after treatment with rupatadine 10 mg or 20 mg for T4NSS, T2OSS, and T6SS. Data are expressed as mean change from baseline over time of treatment for: a T4NSS, b T2OSS, and c T6SS. Statistical significance was calculated with the Mann–Whitney test. *p < 0.05; **p < 0.01 (rupatadine groups vs placebo); ^‡p < 0.05; ^‡‡p < 0.01 (rupatadine 10 mg vs rupatadine 20 mg). T4NSS Total 4 Nasal Symptom Score, T2OSS Total 2 Ocular Symptom Score, T6SS Total 6 Symptom Score