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Fig. 2 | Clinical and Translational Allergy

Fig. 2

From: Histamine H4 receptor regulates IL-6 and INF-γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis

Fig. 2

Blockage effects of H1R, H4R antagonists in U937 cells and human native monocytes with regard to IFN-γ and IL-6 secretion. IFN-γ and IL-6 levels were compared in U937 cells treated with H1R or H4R antagonist alone or combined H1R and H4R antagonists after histamine stimulation (a, d). IFN-γ and IL-6 levels were compared in native monocytes from healthy subjects (b, e) or allergic rhinitis patients (c, f) by treating with H1R or H4R antagonist alone or combined H1R and H4R antagonists after house dust mite (HDM) stimulation. Data are shown as the mean ± SD. #p < 0.05 versus baseline. *p < 0.05, **p < 0.01, ***p < 0.001 versus histamine-stimulated or HDM-stimulated cells

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