Table 1 Conditions and comorbidies considered as contraindications to AIT, by Allergy Societies/Academies (in alphabetical order) and year of publication
AAAAI-2011 | ASCIA-1997 | BSACI (SCIT)-2011 | BSACI (VIT)-2011 | CMICA-2011 | DSA-2005 | EAACI (SCIT)-2015 | EAACI (SLIT)-2015 | EAACI (VIT)-2015 | FSACI-2011 | German-speaking-2014 | IFIACI (SCIT)-2014 | IFIACI (VIT)-2014 | JSA-2017 | NSAI-2011 | PTA (SLIT)-2016 | SEIAC-2011 | SFA-2003 | SFFA-2009 | WHO-1998 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lack of communication | A | A | A | R | R | R | A | A | A | A | R | A | A | A | R | |||||
Start during pregnancy | Ra | R | R | R | R | R | A | A | A | R | Aa | Ab | R | A | R | R | R | R | R | R |
Beta-blockers | R | A | A | R | R | Ac | R | R | Ac | A | R | R | A | R | A | R | A | R | R | |
ACE-inhibitors | R | R | R | R | Ad | R | ||||||||||||||
Antidepressants | R | |||||||||||||||||||
Children < 5-6 yo | R | A | R | Re | Re | Re | Ab | A | R | R | A | Rb | Rc | |||||||
Elderly > 65 yo | R | R | ||||||||||||||||||
Cardiovascular diseases | R | R | A | A | R | R | Ac | R | R | A | A | R | ||||||||
Uncontrolled asthma | R | R | A | A | A | A | A | A | A | A | Ag | A | A | A | R | A | R | A | A | R |
Co-existing active diseases | A | A | A | R | R | R | R | R | A | |||||||||||
Immunodeficiency | R | R | R | A | R | R | R | A | A | A | R | A | R | A | A | R | ||||
Autoimmunity | R | R | R | R | A | Rf | Rf | Rf | R | R | A | R | A | R | A | R | A | A | R | |
Immunosuppressive agents | R | R | R | R | A | A | A | |||||||||||||
Chronic infections | A | R | R | R | A | R | A | A | ||||||||||||
Malignancy | R | R | R | R | A | A | A | R | A | R | A | R | A | R | A | A | ||||
Dermatitis | R | R | R | R | R | R | ||||||||||||||
Temporary conditions | A | R | R | R | ||||||||||||||||
Inadequate means/training | A | A | ||||||||||||||||||
Anaphylaxis to AIT | A |