Table 2 Pathologic conditions associated with reactive hypereosinophilia

Allergic atopic or non-atopic diseases

Eosinophilic asthma, allergic rhinitis, non-allergic rhinitis with eosinophilia syndrome (NARES), food allergies, atopic dermatitis, drug allergies (ex.DRESS), allergic bronchopulmonary aspergillosis (ABPA), eosinophilic chronic rhinosinusitis (ECRS), eosinophilic otitis media, eosinophilic laryngitis

Infections

Parasitic (Toxocara, Toxoplasma, Strongyloides, Ascariasis, Trichinella, Echinococcus, Scabiae, Microfilaria)

Fungal (Coccidioides mycoses) Viral (HIV, HCV)

Autoimmune diseases

Connective tissue disorders, sarcoidosis, inflammatory bowel disease, bullous pemphigoid, systemic vasculitis (Wegener disease, Churg–Strauss syndrome)

Endocrine diseases

Addison’s disease

Hematologic neoplasms

Myeloid: acute/chronic eosinophilic leukemia, chronic myeloid leukemia Ph+, myelodysplastic syndromes, systemic mastocytosis, aggressive mastocytosis, mast cell leukemia

Lymphoid: Hodgkin lymphoma, non-Hodgkin lymphoma, T-cell lymphoma

Solid neoplasms

Adenocarcinoma of the lung, gastro-intestinal tract, pancreas, thyroid, genital and skin tumors

Organ restricted diseases with HE

Esophagitis, gastroenteritis, cystitis, pneumonia, dermatologic conditions

Immunodeficiencies

Hyper IgE syndrome (Job’s syndrome)

Omenn syndrome

Rare diseases

Gleich syndrome (episodic angioedema, eosinophilia, policlonal IgM)

Eosinophilia-Mialgia syndrome

Other

Graft-versus-host disease, Cholesterol embolization, radiation exposure