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Table 2 Pathologic conditions associated with reactive hypereosinophilia

From: Eosinophilic disorders: evaluation of current classification and diagnostic criteria, proposal of a practical diagnostic algorithm

Allergic atopic or non-atopic diseases Eosinophilic asthma, allergic rhinitis, non-allergic rhinitis with eosinophilia syndrome (NARES), food allergies, atopic dermatitis, drug allergies (ex.DRESS), allergic bronchopulmonary aspergillosis (ABPA), eosinophilic chronic rhinosinusitis (ECRS), eosinophilic otitis media, eosinophilic laryngitis
Infections Parasitic (Toxocara, Toxoplasma, Strongyloides, Ascariasis, Trichinella, Echinococcus, Scabiae, Microfilaria)
Fungal (Coccidioides mycoses) Viral (HIV, HCV)
Autoimmune diseases Connective tissue disorders, sarcoidosis, inflammatory bowel disease, bullous pemphigoid, systemic vasculitis (Wegener disease, Churg–Strauss syndrome)
Endocrine diseases Addison’s disease
Hematologic neoplasms Myeloid: acute/chronic eosinophilic leukemia, chronic myeloid leukemia Ph+, myelodysplastic syndromes, systemic mastocytosis, aggressive mastocytosis, mast cell leukemia
Lymphoid: Hodgkin lymphoma, non-Hodgkin lymphoma, T-cell lymphoma
Solid neoplasms Adenocarcinoma of the lung, gastro-intestinal tract, pancreas, thyroid, genital and skin tumors
Organ restricted diseases with HE Esophagitis, gastroenteritis, cystitis, pneumonia, dermatologic conditions
Immunodeficiencies Hyper IgE syndrome (Job’s syndrome)
Omenn syndrome
Rare diseases Gleich syndrome (episodic angioedema, eosinophilia, policlonal IgM)
Eosinophilia-Mialgia syndrome
Other Graft-versus-host disease, Cholesterol embolization, radiation exposure