Terminology | Definition and criteria |
---|---|
Blood eosinophilia | Eosinophils > 0.5 × 109/L |
Hypereosinophilia (HE) | Eosinophils > 1.5 × 109/L in blood on 2 examinations (interval > 1 month) and/or tissue HE defined by the following:  1. Percentage of eosinophils in bone marrow section exceeds 20% of all nucleated cells and/or  2. Extensive tissue infiltration by eosinophils based on pathologist report and/or  3. Marked deposition of eosinophil granule proteins (in the absence or presence of major tissue infiltration by eosinophils) |
Secondary (reactive) HE | Clinical and laboratory evidence for causes of HE:  1. Common allergic, reactive or immunologic conditions  2. Hematopoietic neoplasms  3. Non-hematopoietic neoplasms (paraneoplastic HE)  4. Rare conditions associated with HE |
Hypereosinophilic syndrome (HES) | 1. Criteria for peripheral blood HE fulfilled and 2. Organ damage and/or dysfunction attributable to tissue HE, and 3. Exclusion of secondary (reactive) HE as major reason for organ damage |
HE of undetermined significance | 1. Criteria for peripheral blood HE fulfilled and 2. No clinical symptoms and/or proof of organ dysfunction |
Overlap HE syndromes | Criteria for HES and EGPA (ANCA-negative subtype) |
Associated HE disorders | 1. Criteria of HE fulfilled and 2. Single-organ disease or Secondary (reactive) HE |