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Table 2 Baseline clinical characteristics in patients, who were followed for 12 year (N = 38), with primary or revision ESS at baseline

From: Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis

 

Primary ESS

Revision ESS

P value

N = 19

N = 19

Baseline clinical characteristics (N = 38)

Clinical characteristics

 Men/women, N/N (%/%)

13/6 (68/32)

12/7 (63/37)

1.00

 Age (y), median (IQR)

44 (31–54)

47 (37–53)

0.863

 Comorbidity

  Allergic sensitizaion, N (%)

10 (53)

10 (53)

1.00

  Asthma, N (%)

5 (26)

10 (53)

0.184

  AERD, N (%)

3 (16)

7 (37)

0.269

 Total NP score, median (IQR)

4 (3–5)

4 (4–6)

0.644

 Total symptom score, median (IQR)

8 (7–12)

9 (8–12)

0.443

Tissue biomarkers, median (IQR)

 IL-5 (pg/ml)

86.02 (43.00–237.87)

228.14 (133.24–484.44)

<0.05

 Detectable IL-5, N (%)

10 (53)

16 (84)

0.079

 IL-5Rα (pg/ml)

2704.74 (1116.04–13,162.88)

15,383.50 (4036.26–28,350.59)

<0.05

 TGF-β1 (pg/ml)

8934.18 (7356.03–15,825.42)

12,769.26 (7562.52–27,256.90)

0.477

 MPO (ng/ml)

5251.91 (2634.00–11,020.06)

9255.17 (4602.93–19,868.30)

0.061

 IL-18 (pg/ml)

14,982.30 (7761.63–25,611.80)

15,051.30 (4698.93–19,633.68)

0.354

 ECP (mg/l)

5.71 (0.86–12.93)

13.48 (4.75–28.46)

<0.05

 Total IgE (kU/l)

322.95 (146.30–1348.16)

432.30 (251.83–1156.39)

0.639

 Detectable IgE to SAE, N (%)

8 (42)

8 (42)

1.00

Nasal secretion biomarkers, median (IQR)

 IL-5 (pg/ml)

30.00 (30.00–109.22)

94.81 (30.00–169.86)

0.285

 IL-5Rα (pg/ml)

667.55 (439.40–791.74)

2897.67 (562.93–10,030.07)

0.076

 ECP (mg/l)

0.36 (0.12–0.79)

0.54 (0.32–3.57)

0.100

 IgE (kU/l)

174.15 (40.49–312.94)

324.35 (100.14–662.78)

0.394

Serum biomarkers, median (IQR)

 IL-5 (pg/ml)

BDL

BDL

ND

 IL-5Ra (pg/ml)

334.60 (235.60–710.05)

414.90 (364.30–866.60)

0.471

 ECP (µg/l)

26.10 (21.60–45.15)

23.90 (19.75–189.50)

0.601

 IgE (kU/l)

217.00 (51.15–715.00)

50.20 (29.35–189.50)

0.110

  1. Italic values indicate significance of P value (P < 0.05)
  2. N number, IQR interquartile range, BDL below detection level, ND not done