Skip to main content

Advertisement

Table 5 Meta-regression results

From: Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis

  Combined symptom and medication scores (cSMS) Rhinoconjunctivitis symptom scores (RCSS)
Meta-regression At time of primary analysis in original studies (one measure by study) All pollen seasons included (one measure by pollen season) All pollen seasons included (one measure by pollen season)
Higher difference between depigmented-polymerized allergen extracts and placebo Mean difference 95%CI p-value Mean difference 95%CI p-value Mean difference 95%CI p-value
Asthma score
Intermittent to moderate included (0) Reference category Reference category Reference category
Mild to moderate included (1) 1.4 (0.8 to 1.9) < 0.001 1.7 (1 to 2.4) < 0.001 2.4 (0.3 to 4.5) < 0.001
Only moderate included (2) 2.5 (1.7 to 3.2) < 0.001 2.9 (2.2 to 3.7) < 0.001 2.5 (0.3 to 4.6) < 0.001
Rhinoconjunctivitis
Mild excluded against included 0.8 (0.4 to 1.2) < 0.001 0.7 (0.08 to 1.3) < 0.001 0.9 (− 0.2 to 2) 0.1
Durations of evaluation period
Increasing 1 month 0.1 (0.01 to 0.3) < 0.05 0.1 (− 0.01 to 0.3) < 0.1 Not Significant
Control group sample size
Increasing 10 patients − 0.1 (− 0.2 to 0.0) < 0.05 Not significant Not Significant
Heterogeneity Q test: I2 = 0%
p-value = 0.469
I2 = 18.3%
p-value = 0.13
I2 = 84.15% p-value = 0.003
  1. Statistically significant values are in italics (p ≤ 0.1)