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Fig. 3 | Clinical and Translational Allergy

Fig. 3

From: Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis

Fig. 3

Agreement between cSMS calculated with daily measures from CSR and calculated with total scores in a Scatter plot (a) and Bland–Altman plot (b). From published articles in all study seasons [9,10,11,12,13,14,15,16]. a The points represent the intersection between the two cSMS values (cSMS calculated with daily measures from the CSR and calculated with total scores from published articles). Strong agreement can be observed between the two measurements (ICC: 0.902, 95% CI: 0.14–0.981). b The X-axis represents the sum of two cSMS values divided by two; the Y-axis represents the differences between the two measures of cSMS. Strong agreement between the two measurements can be seen because there are no points outside the 95% limits of agreement (dashed lines). It is common to compute 95% limits of agreement for each comparison (average difference ± 1.96 standard deviation of the difference), which tell us how far apart measurements observed using two methods were more likely to be for different cases. Contrary to expectations, in the articles that published cSMS the two measures are not equal. There are slight differences between cSMS values extracted from clinical study reports (CSRs) and those extracted from publications. This is due to the fact that in the published articles provided only the median and range, and therefore they should be transformed to mean and standard deviation. Whereas in the CSRs the mean and the standard deviation were available. cSMS combined symptoms and medication score, CSR clinical study report, HDM house dust mite, ICC intra-class correlation coefficient

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