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Fig. 3 | Clinical and Translational Allergy

Fig. 3

From: A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow’s milk allergic infants: a randomized controlled trial

Fig. 3

Redundancy analysis (RDA) biplot showing the change in species composition from week 0 to week 8 in saliva samples of infants receiving test or control formula (a). The top 15 OTUs are plotted based on best fit with the first two RDA axes. In bold the OTUs that were significantly different at week 8 between test versus control as confirmed with the two-part statistics method. The proportion of zeros (plotted as bars) and the median of the non-zero values (plotted as points) are displayed for the two differentially abundant OTU’s assigned to Peptostreptococcus (b) and Parabacteroides (c), respectively. False discovery rate (FDR) was used to correct the raw P-values for multiple testing with significance at 0.1. bOnly the Barnard test was performed (if < 5 non-zeros in one group) to compare the proportion of zeros. The OTU‘s are summarized with unique (but arbitrary) numbers as identifiers, and genus level (“_g_”) and phylum level taxonomic assignments: Acti actinobacteria, Bact bacteroidetes, Firm firmicutes, Fuso fusobacteria, Prot proteobacteria, Sacc saccharibacteria

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