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Table 6 Summary table of literature analysis, PICOT question 4: influence of ICS particle size on asthma outcomes

From: Quality standards in respiratory real-life effectiveness research: the REal Life EVidence AssessmeNt Tool (RELEVANT): report from the Respiratory Effectiveness Group—European Academy of Allergy and Clinical Immunology Task Force

ReferenceStatementType of data sourceFinal level of evidence (see Fig. 1)Possible impact on clinical practice (TF opinion)Similar evidence available from RCTs
Van Aalderen et al. [67]See Table 7D-M-AModerateYesNo
Martin et al. [68]See Table 7D-M-AModerateYesNo
Colice et al. [69]See Table 7D-M-AModerateYesNo
Price et al. [70]See Table 7D-M-AModerateYesNo
Price et al. [71]See Table 7D-M-AModerateYesNo
Barnes et al. [40]See Table 7D-M-AModerateYesNo
Price et al. [32]See Table 7D-M-AModerateYesNo
Allegra et al. [72] PC-ALow (selection bias, secondary objective)NoNo