Table 5 Summary table of literature analysis, PICOT question 3: influence of smoking on asthma outcomes in patients receiving ICS therapy
Reference | Statement | Type of data source | Final level of evidence (see Fig. 1) | Possible impact on clinical practice (TF opinion) | Similar evidence available from RCTs |
|---|---|---|---|---|---|
Brusselle et al. [33] | Lower asthma control in smokers but same treatment benefit irrespective of smoking status | PC | Low (see text) | No | No |
Roche et al. [65] | Better outcomes with extra-fine versus standard size particle ICS, larger differences in current and ex-smokers | D-M-A | Moderate | Uncertain (exploratory) | No |