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Table 5 Summary table of literature analysis, PICOT question 3: influence of smoking on asthma outcomes in patients receiving ICS therapy

From: Quality standards in respiratory real-life effectiveness research: the REal Life EVidence AssessmeNt Tool (RELEVANT): report from the Respiratory Effectiveness Group—European Academy of Allergy and Clinical Immunology Task Force

ReferenceStatementType of data sourceFinal level of evidence (see Fig. 1)Possible impact on clinical practice (TF opinion)Similar evidence available from RCTs
Brusselle et al. [33]Lower asthma control in smokers but same treatment benefit irrespective of smoking statusPCLow (see text)NoNo
Roche et al. [65]Better outcomes with extra-fine versus standard size particle ICS, larger differences in current and ex-smokersD-M-AModerateUncertain (exploratory)No