Table 1 Characterization of the three groups included in the study. Comparison of the non-atopic asthmatics (NAA) to non-atopic controls (NAC) and atopic asthmatics (AA)

Females (%)

60

54.1

48.2

0.687

0.398

Age (years)

18.5 ± 5.90

19.5 ± 5.98

18.4 ± 5.80

0.526

0.946

Height (cm)

163 ± 13.6

172 ± 11.5

166 ± 14.3

0.021

0.553

Weight (kg)

59.3 ± 15.9

65.9 ± 16.2

61.6 ± 19.3

0.161

0.646

FeNO (ppb)

9.78 (8.15, 11.7)

10.5 (9.01, 12.3)

29.2 (19.4, 44.2)

0.534

< .001

B-Eos

0.118 (0.088, 0.159)

0.086 (0.067, 0.110)

0.357 (0.257, 0.498)

0.097

< .001

B-Neu

3.23 (2.68, 3.90)

3.13 (2.65, 3.70)

3.26 (2.85, 3.72)

0.796

0.941

Phadiatop

0.053 (0.041, 0.069)

0.046 (0.037, 0.057)

22.8 (12.5, 41.6)

0.349

< .001

fx5

0.054 (0.038, 0.073)

0.053 (0.038, 0.073)

2.77 (0.963, 7.98)

0.627

< .001

Total IgE

22.8 (14.1, 36.6)

15.6 (8.81, 27.7)

458 (334, 628)

0.300

< .001

S-ECP

9.76 (7.62, 12.5)

8.33 (6.02, 11.5)

20.0 (14.9, 26.9)

0.423

< .001

P-CRP

0.510 (0.267,0.973)

0.522 (0.288, 0.945)

0.551 (0.327, 0.928)

0.956

0.846

S-HNL

75.2 (63.0, 89.7)

73.4 (62.7, 86.0)

72.1 (63.6, 81.8)

0.835

0.684

Smoking (%)

0

8.33

6.89

0.146

0.187

ICS (µg)

438 (312, 615)

–

395 (307, 509)

–

0.876

LTRA (%)

24.0

–

20.7

–

0.999

ACT

18.8 ± 4.51

–

20.0 ± 2.89

–

0.140

mAQLQ

5.17 ± 1.20

–

5.74 ± 0.821

–

0.045

FEV₁ (%)

92.7 ± 12.5

98.0 ± 13.5

91.1 ± 16.3

0.156

0.701

FEV₁ < 80 (%)

16.0

4.17

24.1

0.178

0.468

FEV₁/FVC

82.6 (79.5, 85.8)

87.7 (85.4, 90.1)

80.5 (76.8, 84.2)

0.011

0.402

PD₂₀ (mg)

0.677 (0.297, 1.54)

4.56 (3.25, 6.41)

0.393 (0.130, 1.19)

< .001

0.422

Recent asthma attacks

56.0

–

48.2

–

0.320