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Table 1 Percentages of bifidobacteria and ER/CC at weeks 8, 12 and 26 in: (a) subgroup of subjects that did not take systemic antibiotics during the study period; (b) subgroup of subjects that received study product until week 26

From: A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial

(A)

Bacteria (%)

Week

Test (N = 29)

Control (N = 25)

P valuea

HBR (N = 51)

Bifidobacteria, mean [95% CI]

0

28.30

20.75

0.267b

 
 

[18.7–37.9]

[10.8–30.7]

  
 

8

36.31

14.48

0.001

48.08

  

[26.6–46.0]

[6.9–22.1]

 

[40.6–55.5]

 

12

53.09

17.61

0.003

 
  

[40.3–65.9]

[6.3–29.0]

  
 

26

43.28

14.07

< 0.001

 
  

[31.5–55.0]

[7.0–21.2]

  

ER/CC cluster, mean [95% CI]

0

18.48

16.73

0.705b

 
 

[12.3–24.7][

[9.5–24.0]

  
 

8

13.44

24.99

0.014

10.38

  

[8.1–18.8]

[17.7–32.2]

 

[7.4–13.4]

 

12

10.16

34.12

< 0.001

 
  

[4.2–16.1]

[25.0–43.3]

  
 

26

15.92

31.72

0.002

 
  

[10.6–21.2]

[23.5–40]

  

(B)

Bacteria (%)

Week

Test (N = 20)

Control (N = 19)

P valuea

HBR (N = 51)

Bifidobacteria, mean [95% CI]

0

26.63

17.74

0.231b

 
 

[14.8–38.4]

[7.9–27.5]

  
 

8

38.40

13.06

0.002

48.08

  

[23.4–53.4]

[5.9–20.3]

 

[40.6–55.5]

 

12

49.74

17.09

0.002

 
  

[28.0–71.5]

[6.4–27.8]

  
 

26

48.77

15.12

< 0.001

 
  

[37.0–60.6]

[7.0–23.3]

  

ER/CC cluster, mean [95% CI]

0

23.55

13.42

0.074b

 
 

[15.1–32.0]

[5.5–21.3]

  
 

8

6.31

25.52

< 0.001

10.38

  

[3.7–9.0]

[16.8–34.2]

 

[7.4–13.4]

 

12

7.45

32.11

0.002

 
  

[2.1–12.7]

[22.5–41.7]

  
 

26

13.07

33.92

< 0.001

 
  

[8.2–17.9]

[24.8–43.0]

  
  1. HBR healthy, breastfed reference group (infants within a similar age range to subjects in the randomized groups at study week 8 [29]). N is number of subjects, CI confidence interval
  2. aBased on ANCOVA comparing Test versus Control with stratification factor and baseline value as covariate and treatment as fixed effect
  3. bInterference based on t-test